2. Academic Validation
  3. CCL2/CCR2 signaling in cancer pathogenesis

CCL2/CCR2 signaling in cancer pathogenesis

  • Cell Commun Signal. 2020 May 29;18(1):82. doi: 10.1186/s12964-020-00589-8.
Qiongyu Hao 1 2,  Jaydutt V Vadgama 3 4,  Piwen Wang 5 6 7
Affiliations

Affiliations

  • 1 Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA, 90059, USA. qiongyuhao@cdrewu.edu.
  • 2 David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. qiongyuhao@cdrewu.edu.
  • 3 Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA, 90059, USA. jayvadgama@cdrewu.edu.
  • 4 David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. jayvadgama@cdrewu.edu.
  • 5 Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA, 90059, USA. piwenwang@cdrewu.edu.
  • 6 David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA. piwenwang@cdrewu.edu.
  • 7 Center for Human Nutrition, University of California, Los Angeles, CA, 90095, USA. piwenwang@cdrewu.edu.
PMID: 32471499 DOI: 10.1186/s12964-020-00589-8
Abstract

Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of Cancer including prostate Cancer. The progression and metastasis of prostate Cancer involve a complex network of chemokines that regulate the recruitment and trafficking of immune cells. The chemokine CCL2 and its main receptor CCR2 have been receiving particular interest on their roles in Cancer pathogenesis. The up-regulation of CCL2/CCR2 and varied immune conditions in prostate Cancer, are associated with Cancer advancement, metastasis, and relapse. Here we reviewed recent findings, which link CCL2/CCR2 to the inflammation and Cancer pathogenesis, and discussed the therapeutic potential of CCL2/CCR2 axis in Cancer treatment based on results from our group and other investigators, with a major focus on prostate Cancer. Video Abstract.

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