Silencing of CD276 suppresses lung cancer progression by regulating integrin signaling

Background: Non-small cell lung Cancer (NSCLC) is one of the cancers with the highest morbidity and mortality among the world. Studies have shown that the invasion and metastasis of tumor are biological characteristics of lung Cancer, and also the main cause of treatment failure and patient death. In-depth study of lung Cancer invasion related genes will help to explore the etiology of lung Cancer, molecular typing and individualized treatment of lung Cancer. Studies have shown that CD276 molecules are closely related to the prognosis of tumors, but the exact mechanism remains to be unclear.

Methods: We used the UALCAN and KM-plotter databases to investigate the expression of CD276 in human NSCLC and adjacent normal tissues, and its correlation with clinicopathology. In addition, we analyzed the function of CD276 in NSCLC cell by suppressing the expression of CD276 in A549 and H460 cells.

Results: In this study, we found that CD276 expression was significantly up-regulated in NSCLC tissues, and its expression was positively correlated with tumor stage in NSCLC. Silencing in CD276 inhibited cell invasion and migration by reducing integrin-associated protein expression.

Conclusions: Our results indicate functional role of CD276 in the progression of NSCLC.