2. Academic Validation
  3. Cytotoxic Manoalide-Type Sesterterpenes from the Sponge Luffariella variabilis Collected in the South China Sea

Cytotoxic Manoalide-Type Sesterterpenes from the Sponge Luffariella variabilis Collected in the South China Sea

  • J Nat Prod. 2021 Jan 22;84(1):61-70. doi: 10.1021/acs.jnatprod.0c01026.
Xiangchao Luo 1 2,  Qi Wang 1 2 3,  Xuli Tang 4,  Jixiang Xu 1 2,  Mengxue Wang 1 2,  Pinglin Li 1 2,  Guoqiang Li 1 2
Affiliations

Affiliations

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • 2 Laboratory of Marine Drugs and Biological Products, Pilot National Laboratory for Marine Science and Technology, Qingdao 266235, People's Republic of China.
  • 3 Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, People's Republic of China.
  • 4 College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, People's Republic of China.
PMID: 33371684 DOI: 10.1021/acs.jnatprod.0c01026
Abstract

Thirteen new linear terpenes, including 11 rare acyclic manoalide derivatives (1-11), one polyprenylphenol derivative (12), and one polyprenylbenzaldehyde derivative (13), together with three known compounds (14-16) were isolated from the Sponge Luffariella variabilis collected in the South China Sea. The planar structures were resolved by NMR and MS analyses, while the absolute configurations were fully elucidated by NOESY experiments, combined with experimental and calculated ECD spectra, acetal formation, empirical rules of 1H and 13C NMR shifts, DP4+ probability analyses, and Mosher's method. Compounds 1-7, 10, and 13 demonstrated cytotoxic activities against several human Cancer cell lines with IC50 values ranging from 2 to 10 μM.

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