2. Academic Validation
  3. Research progress in biological activities of succinimide derivatives

Research progress in biological activities of succinimide derivatives

  • Bioorg Chem. 2021 Mar:108:104557. doi: 10.1016/j.bioorg.2020.104557.
Zefeng Zhao 1,  Jiangxin Yue 2,  Xiaotong Ji 2,  Meng Nian 2,  Kaiwen Kang 2,  Haifa Qiao 3,  Xiaohui Zheng 4
Affiliations

Affiliations

  • 1 College of Acupuncture & Massage, Shaanxi University of Chinese Medicine, Xixian New Area, Shaanxi Province 712046, PR China; Shaanxi Key Laboratory of Acupuncture & Medicine, Xixian New Area, Shaanxi Province 712046, PR China; School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an 710069, PR China.
  • 2 Shaanxi Key Laboratory of Acupuncture & Medicine, Xixian New Area, Shaanxi Province 712046, PR China.
  • 3 College of Acupuncture & Massage, Shaanxi University of Chinese Medicine, Xixian New Area, Shaanxi Province 712046, PR China; Shaanxi Key Laboratory of Acupuncture & Medicine, Xixian New Area, Shaanxi Province 712046, PR China. Electronic address: 1511006@sntcm.edu.cn.
  • 4 School of Pharmacy, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 229 Taibai Road, Xi'an 710069, PR China.
PMID: 33376010 DOI: 10.1016/j.bioorg.2020.104557
Abstract

Succinimides are well recognized heterocyclic compounds in drug discovery which produce diverse therapeutically related applications in pharmacological practices. Researches in medicinal chemistry field have isolated and synthesized succinimide derivatives with multiple medicinal properties including anticonvulsant, anti-inflammatory, antitumor and antimicrobial agents, 5-HT Receptor ligands and Enzyme inhibitors. Simultaneously, SAR (Structure-Activity Relationship) analysis has been gradually possessed, along with a great deal of derivatives have been derived for potential targets. In this article, we comprehensively summarize the biological activities and SAR for succinimide derivatives, along with the featuring bioactive molecules reported in patents, wishing to provide an overall retrospect and prospect on the succinimide analogues.

Keywords

5-HT receptor ligands; Anti-inflammatory; Antimicrobial; Antitumor; Derivatives; Enzyme inhibitors; SAR; Succinimide.

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