2. Academic Validation
  3. Antiproliferative Activity and Potential Mechanism of Marine-Sourced Streptoglutarimide H against Lung Cancer Cells

Antiproliferative Activity and Potential Mechanism of Marine-Sourced Streptoglutarimide H against Lung Cancer Cells

  • Mar Drugs. 2021 Jan 31;19(2):79. doi: 10.3390/md19020079.
Hengju Ge 1,  Di Zhang 1 2,  Muran Shi 3,  Xiaoyuan Lian 3,  Zhizhen Zhang 1
Affiliations

Affiliations

  • 1 Zhoushan Campus, Ocean College, Zhejiang University, Zhoushan 316021, China.
  • 2 Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China.
  • 3 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
PMID: 33572615 DOI: 10.3390/md19020079
Abstract

In 2019, streptoglutarimide H (SGH) was characterized as a new glutarimide from the secondary metabolites produced by a marine-derived actinomycete Streptomyces sp. ZZ741 and shown to have in vitro antiglioma activity. However, the antiproliferative activity and potential mechanism of SGH against lung Cancer cells have not yet been characterized. This study demonstrated that SGH significantly inhibited the proliferation of different lung Cancer cells. In terms of mechanism of action, SGH downregulated cell cycle- and nucleotide synthesis-related proteins to block cell cycle at G0/G1 phase, reduced the expression levels of glycolytic metabolic Enzymes to inhibit glycolysis, and downregulated the important Cancer transcription factor c-Myc and the therapeutic target Deubiquitinase USP28. Potent Anticancer activity and multiple mechanisms indicated SGH to be a novel antitumor compound against lung Cancer cells.

Keywords

Streptoglutarimide H; USP28; antiproliferative activity; c-Myc; cell cycle block; glycolysis; lung cancer cells.

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