2. Academic Validation
  3. Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi

Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi

  • J Gen Appl Microbiol. 2021 Jul 31;67(3):114-117. doi: 10.2323/jgam.2020.08.004.
Amila Pramisandi 1 2,  Kesi Kurnia 2,  Evita Chrisnayanti 2,  Putri Bernawati 2,  Kazuyuki Dobashi 3,  Mihoko Mori 1 3,  Anis Herliyati Mahsunah 2,  Kenichi Nonaka 1 3,  Atsuko Matsumoto 1 3,  Kristiningrum 2,  Dyah Noor Hidayati 2,  Diana Dewi 2,  Erwahyuni Endang Prabandari 2,  Eri Amalia 4,  Yulia Rahmawati 4,  Arif Nurkanto 4 5,  Daniel Ken Inaoka 4 6 7,  Danang Waluyo 2,  Kiyoshi Kita 4 6 7 8,  Tomoyoshi Nozaki 4,  Satoshi Ōmura 3,  Kazuro Shiomi 1 3
Affiliations

Affiliations

  • 1 Graduate School of Infection Control Sciences, Kitasato University.
  • 2 Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • 3 Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • 4 Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
  • 5 Research Center for Biology, Indonesia Institute of Sciences (LIPI).
  • 6 School of Tropical Medicine and Global Health, Nagasaki University.
  • 7 Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University.
  • 8 Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University.
PMID: 33814517 DOI: 10.2323/jgam.2020.08.004
Abstract

Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol (1), which inhibits Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) with an IC50 value of 3.4 μM. Another Indonesian fungus, Penicillium citrinum BioMCC-f.T.6730, produced an analog of 1, homogentisic acid (4), which also inhibits PfDHODH with an IC50 value of 47.6 μM.

Keywords

Plasmodium falciparum; dihydroorotate dehydrogenase; inhibitor; malaria.

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