2. Academic Validation
  3. Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling

Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling

  • J Cell Physiol. 2021 Nov;236(11):7565-7577. doi: 10.1002/jcp.30397.
Juanjuan Dai 1 2 3,  Yan He 1 2,  Mingjie Jiang 2 4,  Mengya Niu 1 2,  Bin Li 1 2,  Zengkai Wu 1 2,  Jingpiao Bao 1 2,  Li Wen 1 2,  Xingpeng Wang 1 2,  Guoyong Hu 1 2
Affiliations

Affiliations

  • 1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • 2 Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • 3 Department of Intensive Care Unit, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
  • 4 Department of Head and Neck, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
PMID: 33899235 DOI: 10.1002/jcp.30397
Abstract

Pancreatic regeneration after acute pancreatitis is critical in the normal restoration of pancreatic exocrine function, the inhibition of which can cause severe complications including pancreatic exocrine insufficiency. However, the regulators of pancreatic regeneration and the underlying mechanisms remain uncovered. Here, using the inducible Tet-on system, we found that regenerating family member 4 (Reg4) knockdown significantly impaired pancreatic regeneration after pancreatitis. Both acinar-to-ductal metaplasia and the resolution of pancreatitis during regeneration were affected by Reg4 knockdown. Further investigations confirmed that Reg4 exerted its function through regulating Notch activation both in vitro and in vivo. Our study revealed Reg4 as a new regulator and potential therapeutic target for pancreatic regeneration.

Keywords

ADM; Notch; Reg4; cell proliferation; pancreatic regeneration.

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