2. Academic Validation
  3. Two new sesquiterpenes from Sonchus oleraceus and inhibitory mechanism on murine haemangioendothelioma (EOMA) cell lines

Two new sesquiterpenes from Sonchus oleraceus and inhibitory mechanism on murine haemangioendothelioma (EOMA) cell lines

  • Nat Prod Res. 2022 Jun;36(11):2814-2820. doi: 10.1080/14786419.2021.1931186.
Mingming Lei 1,  Qi Wang 1,  Bing Liu 2,  Yuqin Che 3
Affiliations

Affiliations

  • 1 Department of Cardiovascular, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
  • 2 College of Pharmacy, Harbin University of Commerce, Harbin, P.R. China.
  • 3 Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, P. R. China.
PMID: 34039229 DOI: 10.1080/14786419.2021.1931186
Abstract

Sonchus oleraceus is a kind of medicinal and edible plant which is widely distributed. In this study, two new Sesquiterpenes 1 and 2 along with three known compounds 3-5 were isolated from Sonchus oleraceus by the methods of column chromatography. The structures of the two novel compounds were constructed on the basis of HR-MS and NMR spectra. Cytotoxicities of 1 and 2 were assayed on EOMA cell lines and 1 exhibited no inhibitory effect while 2 elicited moderate inhibitory effect on EOMA cells with IC50 value of 26.5 μM. Western Blot assay indicated that 2 could suppress EOMA cell proliferation by inducing Apoptosis through Bax/Caspase-3 pathway.

Keywords

Asteraceae; Sonchus oleraceus; cytotoxicity; sesquiterpenes; western blot.

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