2. Academic Validation
  3. Total Synthesis, Discovery and Biological Evaluation of Daldinin A Derivatives for Improving Hyperglycemia-Induced Endothelial Cell Death

Total Synthesis, Discovery and Biological Evaluation of Daldinin A Derivatives for Improving Hyperglycemia-Induced Endothelial Cell Death

  • Chem Pharm Bull (Tokyo). 2021;69(8):760-767. doi: 10.1248/cpb.c21-00211.
Qianqian Sun 1,  Shuyu Hu 1,  Yu Song 1,  Runqing Zhu 1,  Luohao Li 1,  Jing Li 1,  Tao Zhang 1,  Qinghe Gao 1,  Yakun Wang 1,  Lizhen Fang 1
Affiliations

Affiliation

  • 1 School of Pharmacy, Xinxiang Medical University.
PMID: 34334519 DOI: 10.1248/cpb.c21-00211
Abstract

Daldinins are a novel type of naturally occurring tricyclic heterocycles isolated from Daldinia concentrica. In this study, four daldinin A derivatives with different alkyl side chains were synthesized using the same synthetic protocol. Bioactivity tests first indicated that the daldinin A derivatives showed significant protection for endothelial cells against damage caused by high glucose. The derivative compound with three carbon atoms on the alkyl side exhibited the best effect.

Keywords

bioactivity; daldinin; endothelial cell; natural product derivative; total synthesis.

Figures
Products