2. Academic Validation
  3. Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

  • Eur J Med Chem. 2021 Dec 15:226:113837. doi: 10.1016/j.ejmech.2021.113837.
Yichao Wan 1,  Guoqing Fang 2,  Hongjuan Chen 2,  Xu Deng 2,  Zilong Tang 2
Affiliations

Affiliations

  • 1 Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan, 411201, PR China; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan, 411201, PR China. Electronic address: 07wanyichao@hnust.edu.cn.
  • 2 Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan, 411201, PR China; Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan, 411201, PR China.
PMID: 34530384 DOI: 10.1016/j.ejmech.2021.113837
Abstract

Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer agents are major challenges for Cancer treatment, which energizes medicinal chemists to develop more anti-cancer agents with high efficiency and low toxicity continuously. Sulfonamide derivatives are a class of promising compounds with diverse biological activities including anti-cancer, and parts of them have been marketed for Cancer therapy, such as Belinostat, ABT-199 and Amsacrine. In this review, we summed up the recent advances of sulfonamide derivatives as potential anti-cancer agents based on the anti-cancer targets, such as aromatase, Carbonic Anhydrase (CA), anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins, Topoisomerase and phosphatidylinositol 3-kinase (PI3K), and elucidated the corresponding structure-activity relationships (SARs) of most sulfonamide derivatives. We hope this review could provide a clear insight for medicinal chemists in the rational design of more potent and bio-target specific anti-cancer agents.

Keywords

Anti-Cancer; Drug design; Structure-activity relationships; Sulfonamide.

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