2. Academic Validation
  3. Long noncoding RNA SNHG3 promotes malignant phenotypes in cervical cancer cells via association with YAP1

Long noncoding RNA SNHG3 promotes malignant phenotypes in cervical cancer cells via association with YAP1

  • Hum Cell. 2022 Jan;35(1):320-332. doi: 10.1007/s13577-021-00644-7.
Hongyu Zhu 1,  Chenyu Zhu 2,  Xiang Feng 3,  Youzhen Luo 4
Affiliations

Affiliations

  • 1 Gynecology Second Ward, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443003, Hubei, China. hongyuzhu@ctgu.edu.cn.
  • 2 Gastrointestinal Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443003, Hubei, China.
  • 3 Obstetrics Department, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443003, Hubei, China.
  • 4 Gynecology Second Ward, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443003, Hubei, China. 176263548@qq.com.
PMID: 34816392 DOI: 10.1007/s13577-021-00644-7
Abstract

Long non-coding RNA (LncRNA) Small Nucleolar RNA Host Gene 3 (SNHG3) is involved in the occurrence and development of various cancers. However, the exact function and mechanism of SNHG3 in cervical Cancer (CC) are still unclear. In this context, we identified a significant increase of SNHG3 expression in CC tissues. Upregulation of SNHG3 expression was associated with advanced FIGO stage and metastasis, and indicated poor overall survival of the CC patients. Functionally, SNHG3 enhanced the proliferation, migration and invasion of CC cells in vitro, and facilitated CC growth in vivo. Further investigation uncovered that SNHG3 interacted with oncoprotein YAP1, thus suppressing its degradation. Additionally, SNHG3 modulated the transcription of several target genes of YAP1. The oncogenic role of SNHG3 was partially attributable to YAP1. Taken together, our research revealed the prognostic and functional roles for SNHG3 in CC, suggesting that SNHG3 could serve as a biomarker for prognosis and a therapeutic target for CC.

Keywords

Invasion; Migration; Proliferation; Protein stability.

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