2. Academic Validation
  3. Review of anticancer activity of monoterpenoids: Geraniol, nerol, geranial and neral

Review of anticancer activity of monoterpenoids: Geraniol, nerol, geranial and neral

  • Chem Biol Interact. 2022 Aug 1:362:109994. doi: 10.1016/j.cbi.2022.109994.
Gabriel Dos Santos E Silva 1,  Joane Nátaly de Jesus Marques 1,  Emily Pacelli Moreira Linhares 1,  Carolina Martinez Bonora 1,  Érico Tosoni Costa 2,  Mauricio Frota Saraiva 3
Affiliations

Affiliations

  • 1 Institute of Physics and Chemistry, Federal University of Itajubá, Itajubá, Brazil.
  • 2 Molecular Oncology Center, Hospital Sírio Libânes, São Paulo, Brazil.
  • 3 Institute of Physics and Chemistry, Federal University of Itajubá, Itajubá, Brazil. Electronic address: mauriciosaraiva@unifei.edu.br.
PMID: 35661738 DOI: 10.1016/j.cbi.2022.109994
Abstract

In recent years head-to-tail monoterpene geraniol has been widely explored as a potential Anticancer agent. Natural analogs like alcohol nerol, aldehydes geranial, and neral have been investigated. We explored the synergism of these terpenes with clinically and non-clinically used compounds as potential candidates for treating different types of Cancer. Promising activity for these compounds has also inspired new analog syntheses. The Anticancer potential of these compounds is described in this review.

Keywords

Cancer; Geranial; Geraniol; Neral; Nerol; Terpenes.

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