2. Academic Validation
  3. Investigating the Anticancer Potential of Salvicine as a Modulator of Topoisomerase II and ROS Signaling Cascade

Investigating the Anticancer Potential of Salvicine as a Modulator of Topoisomerase II and ROS Signaling Cascade

  • Front Oncol. 2022 Jun 1:12:899009. doi: 10.3389/fonc.2022.899009.
Dipta Dey 1,  Mohammad Mehedi Hasan 2,  Partha Biswas 3 4,  Stavros P Papadakos 5,  Rehab A Rayan 6,  Sabiha Tasnim 7,  Muhammad Bilal 8,  Mohammod Johirul Islam 2,  Farzana Alam Arshe 9,  Efat Muhammad Arshad 9,  Maisha Farzana 10,  Tanjim Ishraq Rahaman 11,  Sumit Kumar Baral 12,  Priyanka Paul 1,  Shabana Bibi 13 14,  Md Ataur Rahman 15 16 17,  Bonglee Kim 16 17
Affiliations

Affiliations

  • 1 Biochemistry and Molecular Biology department, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalgonj, Bangladesh.
  • 2 Department of Biochemistry and Molecular Biology, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
  • 3 Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology (JUST), Jashore, Bangladesh.
  • 4 ABEx Bio-Research Center, East Azampur, Dhaka, Bangladesh.
  • 5 First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens (NKUA), Athens, Greece.
  • 6 Department of Epidemiology, High Institute of Public Health, Alexandria University, Alexandria, Egypt.
  • 7 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
  • 8 College of Pharmacy, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
  • 9 Department of Biochemistry and Microbiology, North South University, Dhaka, Bangladesh.
  • 10 College of Medical, Veterinary and Life Sciences, University of Glasgow, University Avenue, Glasgow, United Kingdom.
  • 11 Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
  • 12 Microbiology department, Jagannath University, Dhaka, Bangladesh.
  • 13 Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming, China.
  • 14 Department of Biological Sciences, International Islamic University, Islamabad, Pakistan.
  • 15 Global Biotechnology & Biomedical Research Network (GBBRN), Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia, Bangladesh.
  • 16 Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
  • 17 Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
PMID: 35719997 DOI: 10.3389/fonc.2022.899009
Abstract

Salvicine is a new diterpenoid quinone substance from a natural source, specifically in a Chinese herb. It has powerful growth-controlling abilities against a broad range of human Cancer cells in both in vitro and in vivo environments. A significant inhibitory effect of salvicine on multidrug-resistant (MDR) cells has also been discovered. Several research studies have examined the activities of salvicine on Topoisomerase II (Topo II) by inducing Reactive Oxygen Species (ROS) signaling. As opposed to the well-known Topo II toxin etoposide, salvicine mostly decreases the catalytic activity with a negligible DNA breakage effect, as revealed by several enzymatic experiments. Interestingly, salvicine dramatically reduces lung metastatic formation in the MDA-MB-435 orthotopic lung Cancer cell line. Recent investigations have established that salvicine is a new non-intercalative Topo II toxin by interacting with the ATPase domains, increasing DNA-Topo II interaction, and suppressing DNA relegation and ATP hydrolysis. In addition, investigations have revealed that salvicine-induced ROS play a critical role in the anticancer-mediated signaling pathway, involving Topo II suppression, DNA damage, overcoming multidrug resistance, and tumor cell adhesion suppression, among Other things. In the current study, we demonstrate the role of salvicine in regulating the ROS signaling pathway and the DNA damage response (DDR) in suppressing the progression of Cancer cells. We depict the mechanism of action of salvicine in suppressing the DNA-Topo II complex through ROS induction along with a brief discussion of the Anticancer perspective of salvicine.

Keywords

DNA damage response (DDR); ROS signaling; anticancer properties; diterpenoid quinone; multidrug-resistant (MDR); topoisomerase II.

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