2. Academic Validation
  3. Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota

Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota

  • Commun Biol. 2022 Jul 8;5(1):680. doi: 10.1038/s42003-022-03602-7.
Chen Song 1 2 3,  Fangyuan Duan 1 2 3,  Ting Ju 1 2 3,  Yue Qin 1 2 3,  Deyong Zeng 1 2 3,  Shan Shan 1 2 3,  Yudong Shi 1 2 3,  Yingchun Zhang 1 2 3,  Weihong Lu 4 5 6
Affiliations

Affiliations

  • 1 School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China.
  • 2 Department of Food Science and Engineering, School of Medicine and Health, Harbin Institute of Technology, Harbin, China.
  • 3 National and Local Joint Engineering Laboratory for Synthesis, Transformation, and Separation of Extreme Environmental Nutrients, Harbin Institute of Technology, Harbin, 150001, China.
  • 4 School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China. lwh@hit.edu.cn.
  • 5 Department of Food Science and Engineering, School of Medicine and Health, Harbin Institute of Technology, Harbin, China. lwh@hit.edu.cn.
  • 6 National and Local Joint Engineering Laboratory for Synthesis, Transformation, and Separation of Extreme Environmental Nutrients, Harbin Institute of Technology, Harbin, 150001, China. lwh@hit.edu.cn.
PMID: 35804021 DOI: 10.1038/s42003-022-03602-7
Abstract

Radiation affects not only cognitive function but also gut microbiota. Eleutheroside E (EE), a principal active compound of Acanthopanax senticosus, has a certain protective effect on the nervous system. Here, we find a four-week EE supplementation to the 60Co-γ ray irradiated mice improves the cognition and spatial memory impairments along with the protection of hippocampal neurons, remodels the gut microbiota, especially changes of Lactobacillus and Helicobacter, and altered the microbial metabolites including neurotransmitters (GABA, NE, ACH, 5-HT) as well as their precursors. Furthermore, the fecal transplantation of EE donors verifies that EE alleviated cognition and spatial memory impairments, and activates the PKA/CREB/BDNF signaling via gut microbiota. Our findings provide insight into the mechanism of EE effect on the gut-brain axis and underpin a proposed therapeutic value of EE in cognitive and memory impairments induced by radiation.

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