2. Academic Validation
  3. LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer

LncRNA SNHG1 Facilitates Tumor Proliferation and Represses Apoptosis by Regulating PPARγ Ubiquitination in Bladder Cancer

  • Cancers (Basel). 2022 Sep 28;14(19):4740. doi: 10.3390/cancers14194740.
Hongzhou Cai 1,  Haifei Xu 2,  Hongcheng Lu 3,  Weizhang Xu 1,  Haofeng Liu 4,  Xinwei Wang 5,  Guoren Zhou 5,  Xuejian Yang 6
Affiliations

Affiliations

  • 1 Department of Urology, Jiangsu Cancer Hospital & The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research, Nanjing 210009, China.
  • 2 Department of Urology, Nantong Tumor Hospital, Nantong 226361, China.
  • 3 Department of Urology, Zhongda Hospital Affiliated to Southeastern China University, Nanjing 210029, China.
  • 4 Department of General Surgery, Nantong Tumor Hospital, Nantong 226361, China.
  • 5 Department of Oncology, Jiangsu Cancer Hospital & The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research, Nanjing 210009, China.
  • 6 Department of Urology, Suqian First Hospital, Suqian 223800, China.
PMID: 36230661 DOI: 10.3390/cancers14194740
Abstract

Background: Long noncoding RNAs regulate various biological effects in the progression of cancers. We found that the expression of SNHG1 was significantly up-regulated in bladder Cancer after analyzing data obtained from TCGA and GEO. However, the potential role of SNHG1 remains to be investigated in bladder Cancer. It was validated that SNHG1 was overexpressed in bladder Cancer tissues detected by qRT-PCR and FISH, which was also associated with poor clinical outcome. Additionally, SNHG1 was verified to facilitate tumor proliferation and repress Apoptosis in vitro and in vivo.

Results: SNHG1 could act as a competitive endogenous RNA and decrease the expression of murine double minute 2 (MDM2) by sponging microRNA-9-3p. Furthermore, MDM2 induced ubiquitination and degradation of PPARγ that contributed to the development of bladder Cancer.

Conclusions: the study elucidated that SNHG1 played an important role in bladder Cancer and provided a potential therapeutic target for bladder Cancer.

Keywords

MDM2; PPARγ; SNHG1; bladder cancer; microRNA-9-3p.

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