2. Anti-infection
  3. Antibiotic Bacterial
  4. Streptomycin

Streptomycin  (Synonyms: Agrept; Agrimycin; Streptomycin A)

Cat. No.: HY-B1906 Purity: 99.88%
SDS COA Handling Instructions

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Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .

For research use only. We do not sell to patients.

Streptomycin Chemical Structure

Streptomycin Chemical Structure

CAS No. : 57-92-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
100 mg USD 50 In-stock
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Based on 25 publication(s) in Google Scholar

Other Forms of Streptomycin:

Streptomycin Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes [1][2][3].

IC50 & Target

Aminoglycoside

 

Cellular Effect
Cell Line Type Value Description References
J774.A1 CC50
> 1000 μg/mL
Compound: Streptomycin
Cytotoxicity against mouse J774A1 cells after 24 to 72 hrs by MTT assay
Cytotoxicity against mouse J774A1 cells after 24 to 72 hrs by MTT assay
[PMID: 20934344]
Vero IC50
> 100 μg/mL
Compound: SM
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
[PMID: 24087924]
Vero IC50
> 120 μg/mL
Compound: streptomycin
Cytotoxicity against Vero cells after 48 hrs by XTT method
Cytotoxicity against Vero cells after 48 hrs by XTT method
[PMID: 17888665]
Vero IC50
> 50 μg/mL
Compound: Streptomycin
Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
[PMID: 24044875]
In Vitro

Streptomycin is a potent inhibitor of the hypotonicity-induced Ca2+entry and Cl? channel activity[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Streptomycin Related Antibodies
Clinical Trial
Molecular Weight

581.57

Formula

C21H39N7O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(N)N[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)O)NC(N)=N)O)[C@H]1O[C@H](O[C@H]([C@]2(O)C=O)C)[C@@H]2O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (214.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7195 mL 8.5974 mL 17.1948 mL
5 mM 0.3439 mL 1.7195 mL 3.4390 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

SDS (394 KB)

COA (258 KB) HNMR (303 KB) RP-HPLC (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7195 mL 8.5974 mL 17.1948 mL 42.9871 mL
5 mM 0.3439 mL 1.7195 mL 3.4390 mL 8.5974 mL
10 mM 0.1719 mL 0.8597 mL 1.7195 mL 4.2987 mL
15 mM 0.1146 mL 0.5732 mL 1.1463 mL 2.8658 mL
20 mM 0.0860 mL 0.4299 mL 0.8597 mL 2.1494 mL
25 mM 0.0688 mL 0.3439 mL 0.6878 mL 1.7195 mL
30 mM 0.0573 mL 0.2866 mL 0.5732 mL 1.4329 mL
40 mM 0.0430 mL 0.2149 mL 0.4299 mL 1.0747 mL
50 mM 0.0344 mL 0.1719 mL 0.3439 mL 0.8597 mL
60 mM 0.0287 mL 0.1433 mL 0.2866 mL 0.7165 mL
80 mM 0.0215 mL 0.1075 mL 0.2149 mL 0.5373 mL
100 mM 0.0172 mL 0.0860 mL 0.1719 mL 0.4299 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Streptomycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Streptomycin57-92-1Agrept Agrimycin Streptomycin AAntibioticBacterialSTRantibioticM. tuberculosistuberculosis (TB)bacteriocidal agentbacterialinfectionprotein synthesisRNADNAneuronscardiac myocytesInhibitorinhibitorinhibit

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