Penicillin G (Synonyms: Benzylpenicillin)

Cat. No.: HY-N7139: FAQs
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Penicillin G is a potent penicillinantibiotic. Penicillin G can be used for bacterial infection. Penicillin G has potent activity against all Gram-positive bacteria and Gram-negative cocci.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Penicillin G potassium and Penicillin G sodium salt) that retains the same biological activity.

For research use only. We do not sell to patients.

Penicillin G Chemical Structure

CAS No. : 61-33-6

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Other In-stock Forms of Penicillin G:

Penicillin G potassium Penicillin G sodium salt

Other Forms of Penicillin G:

Penicillin G potassium In-stock
Penicillin G sodium salt In-stock
Streptomycin Get quote
Penicillin G procaine hydrate Get quote
Penicillin G benzathine Get quote
Penicillin G benzathine tetrahydrate Get quote
Penicillin G-d₇ potassium Get quote

13 Publications Citing Use of MCE Penicillin G

•Eur Rev Med Pharmaco. 2019 Sep;23(17):7419-7429. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Penicillin G is a potent penicillinantibiotic. Penicillin G can be used for bacterial infection. Penicillin G has potent activity against all Gram-positive bacteria and Gram-negative cocci^[1]^[2].

IC₅₀ & Target

β-lactam

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	> 10000 μM Compound: PNC	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay	[PMID: 24953953]
HepG2	IC₅₀	> 10000 μM Compound: PNC	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 25593095]
Macrophage	IC₅₀	185.72 μM Compound: Penicillin G	Cytotoxicity against human macrophages assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human macrophages assessed as cell viability after 24 hrs by MTT assay	[PMID: 25306465]
Macrophage	CC₅₀	228.9 μM Compound: Penicillin G	Cytotoxicity against human macrophages after 24 hrs by MTT assay Cytotoxicity against human macrophages after 24 hrs by MTT assay	[PMID: 24561667]

In Vitro

Penicillin G (16-128 μg/mL, 0-20 h) is used in combination with promethazine (32 μg/mL) to inhibit the growth and viability of E. coli^[2].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

334.39

Formula

C₁₆H₁₈N₂O₄S

CAS No.

61-33-6

SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li D, et al. Determination of penicillin G and its degradation products in a penicillin production wastewater treatment plant and the receiving river. Water Res. 2008 Jan;42(1-2):307-17. [Content Brief]

[2]. Lehtinen J, et al. Promethazine renders Escherichia coli susceptible to penicillin G: real-time measurement of bacterial susceptibility by fluoro-luminometry. Int J Antimicrob Agents. 2007 Jul;30(1):44-51. [Content Brief]

Penicillin G Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penicillin G61-33-6BenzylpenicillinAntibioticBacterialpenicillinantibioticbacterialGram-positiveGram-negative cocciE. coliInhibitorinhibitorinhibit

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