2. Academic Validation
  3. Hyperforin: A natural lead compound with multiple pharmacological activities

Hyperforin: A natural lead compound with multiple pharmacological activities

  • Phytochemistry. 2023 Feb;206:113526. doi: 10.1016/j.phytochem.2022.113526.
Xin-Xin Li 1,  Yu Yan 2,  Jia Zhang 3,  Kang Ding 3,  Cong-Yuan Xia 2,  Xue-Ge Pan 3,  Yan-Jing Shi 3,  Jie-Kun Xu 4,  Jun He 5,  Wei-Ku Zhang 6
Affiliations

Affiliations

  • 1 Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, PR China.
  • 2 Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China.
  • 3 School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, PR China.
  • 4 School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, PR China. Electronic address: xjkbucm@163.com.
  • 5 Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China. Electronic address: 15010297582@126.com.
  • 6 Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, PR China. Electronic address: cpuzwk@163.com.
PMID: 36442576 DOI: 10.1016/j.phytochem.2022.113526
Abstract

Hypericum perforatum L. (Clusiaceae), commonly known as St. John's wort, has a rich historical background as one of the oldest and most widely studied herbal medicines. Hyperforin is the main antidepressant active ingredient of St. John's wort. In recent years, hyperforin has attached increasing attention due to its multiple pharmacological activities. In this review, the information on hyperforin was systematically summarized. Hyperforin is considered to be a lead compound with diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes and Others. It can be obtained by extraction and synthesis. Further pharmacological studies and more precise detection methods will help develop a value for hyperforin. In addition, structural modification and pharmaceutical preparation technology will be beneficial to promoting the research progress of hyperforin based innovative drugs. Although these works are full of known and unknown challenges, researchers are still expected to make hyperforin play a greater value.

Keywords

Clusiaceae; Detection methods; Hyperforin; Hypericum perforatum; Pharmacokinetics; Pharmacological activities; Synthesis.

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