2. Academic Validation
  3. A natural allele of proteasome maturation factor improves rice resistance to multiple pathogens

A natural allele of proteasome maturation factor improves rice resistance to multiple pathogens

  • Nat Plants. 2023 Jan 16. doi: 10.1038/s41477-022-01327-3.
Xiao-Hong Hu # 1,  Shuai Shen # 1,  Jin-Long Wu # 1,  Jie Liu # 1,  He Wang # 1,  Jia-Xue He 1,  Zong-Lin Yao 1,  Yi-Fei Bai 1,  Xin Zhang 1,  Yong Zhu 1,  Guo-Bang Li 1,  Jing-Hao Zhao 1,  Xiaoman You 2,  Jie Xu 1 3,  Yun-Peng Ji 1,  De-Qiang Li 1,  Mei Pu 1,  Zhi-Xue Zhao 1,  Shi-Xin Zhou 1,  Ji-Wei Zhang 1,  Yan-Yan Huang 1,  Yan Li 1,  Yuese Ning 2,  Yanli Lu 1 3,  Fu Huang 1 4,  Wen-Ming Wang 5,  Jing Fan 6
Affiliations

Affiliations

  • 1 State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, China.
  • 2 State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
  • 3 Maize Research Institute, Sichuan Agricultural University, Chengdu, China.
  • 4 College of Agronomy, Sichuan Agricultural University, Chengdu, China.
  • 5 State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, China. j316wenmingwang@sicau.edu.cn.
  • 6 State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University, Chengdu, China. fanjing13971@sicau.edu.cn.
  • # Contributed equally.
PMID: 36646829 DOI: 10.1038/s41477-022-01327-3
Abstract

Crops with broad-spectrum resistance loci are highly desirable in agricultural production because these loci often confer resistance to most races of a pathogen or multiple pathogen species. Here we discover a natural allele of Proteasome maturation factor in rice, UMP1R2115, that confers broad-spectrum resistance to Magnaporthe oryzae, Rhizoctonia solani, Ustilaginoidea virens and Xanthomonas oryzae pv. oryzae. Mechanistically, this allele increases Proteasome abundance and activity to promote the degradation of reactive oxygen species-scavenging Enzymes including peroxidase and catalase upon pathogen Infection, leading to elevation of H2O2 accumulation for defence. In contrast, inhibition of Proteasome function or overexpression of peroxidase/catalase-encoding genes compromises UMP1R2115-mediated resistance. More importantly, introduction of UMP1R2115 into a disease-susceptible rice variety does not penalize grain yield while promoting disease resistance. Our work thus uncovers a broad-spectrum resistance pathway integrating de-repression of plant immunity and provides a valuable genetic resource for breeding high-yield rice with multi-disease resistance.

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