2. Academic Validation
  3. Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule

Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule

  • Biomed Pharmacother. 2023 Apr:160:114332. doi: 10.1016/j.biopha.2023.114332.
Parteek Prasher 1,  Mousmee Sharma 2,  Amit Kumar Sharma 3,  Javad Sharifi-Rad 4,  Daniela Calina 5,  Christophe Hano 6,  William C Cho 7
Affiliations

Affiliations

  • 1 Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun 248007, India. Electronic address: parteekchemistry@gmail.com.
  • 2 Department of Chemistry, Uttaranchal University, Arcadia Grant, Dehradun 248007, India. Electronic address: mousmee.sharma90@gmail.com.
  • 3 Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun 248007, India. Electronic address: amit.orgchemistry@gmail.com.
  • 4 Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. Electronic address: javad.sharifirad@gmail.com.
  • 5 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. Electronic address: calinadaniela@gmail.com.
  • 6 Laboratoire de Biologie Des Ligneux Et Des Grandes Cultures (LBLGC), INRA USC1328 Université ď Orléans, 45067 Orléans Cedex 2, France. Electronic address: hano@univ-orleans.fr.
  • 7 Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong. Electronic address: chocs@ha.org.hk.
PMID: 36736282 DOI: 10.1016/j.biopha.2023.114332
Abstract

In the modern era, Cancer can be controlled by chemotherapy treatment, and in many situations a stable disease is obtained. The significant clinical success and subsequent commercialization of naturally derived molecules have further encouraged their exploration as adjunctive therapies in Cancer management. The purpose of this comprehensive review is to update the Anticancer mechanisms triggered by Erinacine A and regulation of signaling pathways potentially involved in its Anticancer activity.The results of preclinical research showed that Erinacin A, a therapeutically important biological metabolite isolated from the basidiomycete fungus Hericium erinaceus offers a multitude of possible chemotherapeutic applications by regulating complex signaling pathways as validated by various pharmacological in vitro and in vivo studies. As a result of Erinacin A's action on oncological signaling pathways, it resulted in induction of Apoptosis, reduction of proliferation, invasiveness, generation of oxidative stress and cell cycle arrest in Cancer cells.

Keywords

Anticancer mechanisms; Apoptosis; Cancer signalling pathways; Erinacine A.

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