2. Apoptosis MAPK/ERK Pathway NF-κB Epigenetics Immunology/Inflammation
  3. Apoptosis JNK NF-κB Histone Acetyltransferase NO Synthase Bcl-2 Family p38 MAPK Caspase
  4. (+)-Erinacin A

(+)-Erinacin A  (Synonyms: Erinacine A)

Cat. No.: HY-111954 Purity: 99.97%
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(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage.

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(+)-Erinacin A Chemical Structure

(+)-Erinacin A Chemical Structure

CAS No. : 156101-08-5

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Based on 1 publication(s) in Google Scholar

(+)-Erinacin A Related Antibodies

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Description

(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage[1][2][3][4][5].

In Vitro

(+)-Erinacin A (30 μM; 3-24 h) activates the extrinsic and intrinsic apoptosis pathways in DLD-1 cells and reduces the expression of anti-apoptotic proteins[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-Erinacin A Related Antibodies

Western Blot Analysis[1]

Cell Line: DLD-1 Cells
Concentration: 30 µM
Incubation Time: 3-24 h
Result: Increased active forms of caspase-3, caspase-9 and caspase-8.
Decreased the expression of the antiapoptotic proteins Bcl-2 and Bcl-XL.
Upregulated the levels of phosphorylated JNK Thr183 and Tyr185, NFκB, and p300 proteins.
In Vivo

(+)-Erinacin A (1, 5 and 10 mg/kg, i.p.; single dose) inhibits neuronal cell death in SAM rats with transient stroke and suppresses the expression of inflammatory cytokines in SAM brain tissues with transient stroke[4].
(+)-Erinacin A (1, 2 and 5 mg/kg, i.p.; once a day for 5 days) significantly reduces tumor volume in DLD-1 xenograft mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DLD-1 xenograft mouse model[5].
Dosage: 1, 2 and 5 mg/kg
Administration: Intraperitoneal injection (i.p.) once a day for 5 days
Result: Inhibited tumor volume by 60%, 32% and 26%.
Animal Model: SAM rats with transient stroke[4].
Dosage: 1, 5 and 10 mg/kg
Administration: Intraperitoneal injection (i.p.) single dose
Result: Induced NeuN immune response in the entire brain region of SAM rats, and increased the number of NeuN cells.
Inhibited the activation of iNOS and p38/MAPK pathways and the expression of CHOP and nitrotyrosine proteins in rat brain tissue.
Molecular Weight

432.55

Formula

C25H36O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@](CC[C@]3(C)C4=C(C(C)C)CC3)(C)C4=CC=C(C=O)C2)OC1
Structure Classification
Initial Source

Hericium erinaceus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 10 mg/mL (23.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3119 mL 11.5594 mL 23.1187 mL
5 mM 0.4624 mL 2.3119 mL 4.6237 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.3119 mL 11.5594 mL 23.1187 mL 57.7968 mL
5 mM 0.4624 mL 2.3119 mL 4.6237 mL 11.5594 mL
10 mM 0.2312 mL 1.1559 mL 2.3119 mL 5.7797 mL
15 mM 0.1541 mL 0.7706 mL 1.5412 mL 3.8531 mL
20 mM 0.1156 mL 0.5780 mL 1.1559 mL 2.8898 mL
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(+)-Erinacin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Erinacin A156101-08-5Erinacine AApoptosisJNKNF-κBHistone AcetyltransferaseNO SynthaseBcl-2 Familyp38 MAPKCaspasec-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBHATsHATNitric oxide synthasesNOSAnticancerErinacin AHericium erinaceumInhibitorinhibitorinhibit

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