2. Academic Validation
  3. miR-1187 induces podocyte injury and diabetic nephropathy through autophagy

miR-1187 induces podocyte injury and diabetic nephropathy through autophagy

  • Diab Vasc Dis Res. 2023 May-Jun;20(3):14791641231172139. doi: 10.1177/14791641231172139.
Bin Chen 1 2,  Qiang He 1 3
Affiliations

Affiliations

  • 1 Medical College of Soochow University, Suzhou, China.
  • 2 Ningbo Zhenhai People's Hospital (Ningbo No.7 Hospital), Zhejiang, China.
  • 3 Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Hangzhou, China.
PMID: 37208852 DOI: 10.1177/14791641231172139
Abstract

MicroRNAs plays important roles in the progression of diabetic nephropathy (DN) and podocyte injury. This study aimed to investigate the role and regulation mechanism of miR-1187 during the development of DN and podocyte injury. The content of miR-1187 in podocytes was up-regulated under high glucose (HG) treatment and increased in kidney tissue of db/db mice (DN model mice) compared with control db/m mice. The administration of miR-1187 inhibitor could decrease podocyte Apoptosis induced by HG and attenuate the decline in renal function and reduce proteinuria as well as glomerular Apoptosis in db/db mice. Mechanistically, miR-1187 could inhibit the Autophagy level in HG-exposed podocytes and glomerulus of DN mice. Moreover, miR-1187 inhibitor could reduce HG-stimulated podocyte injury and Autophagy flux inhibition. The mechanism may depend on Autophagy. In conclusion, targeting miR-1187 may be a new therapeutic target for improving the high glucose damage of podocytes and the progression of DN.

Keywords

Diabetic nephropathy; MiR-1187; autophagy; podocyte injury.

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