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  3. Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings

  • J Mater Chem B. 2023 Aug 2;11(30):7144-7159. doi: 10.1039/d3tb00926b.
Dalia A Elsherbiny 1 2,  Abdelrahman M Abdelgawad 3 4 5,  Bahaa A Hemdan 6,  Ahmed S Montaser 3,  Ibrahim El-Tantawy El-Sayed 1,  Stefan Jockenhoevel 2 7,  Samaneh Ghazanfari 2 7
Affiliations

Affiliations

  • 1 Department of Chemistry, Faculty of Science, Menoufia University, Egypt.
  • 2 Aachen-Maastricht Institute for Biobased Materials, Faculty of Science and Engineering, Maastricht University, The Netherlands. Samaneh.ghazanfari@maastrichtuniversity.nl.
  • 3 Textile Research and Technology Institute, National Research Centre (Affiliation ID: 60014618), Dokki, Cairo, Egypt. aabdelg@ncsu.edu.
  • 4 Textile Engineering Chemistry and Science Department, Wilson College of Textiles, North Carolina State University, Raleigh, NC, USA.
  • 5 Chemistry Department, Faculty of Science, New Mansoura University, New Mansoura City 35511, Egypt.
  • 6 Water Pollution Research Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.
  • 7 Department of Biohybrid & Medical Textiles (BioTex), AME-Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Forckenbeckstrabe 55, 52072 Aachen, Germany.
PMID: 37403540 DOI: 10.1039/d3tb00926b
Abstract

Microbial Infection is the most common obstacle in the wound healing process, leading to wound healing impairment and complications and ultimately increasing morbidity and mortality. Due to the rising number of pathogens evolving resistance to the existing Antibiotics used for wound care, alternative approaches are urgently required. In this study, α-aminophosphonate derivatives as antimicrobial agents were synthesized and incorporated into self-crosslinked tri-component cryogels composed of fully hydrolyzed polyvinyl alcohol (PVA-F), partially hydrolyzed polyvinyl alcohol (PVA-P), and cellulose nanofibrils (CNFs). Initially, the antimicrobial activity of four α-aminophosphonate derivatives against selected skin Bacterial species was tested and their minimum inhibitory concentration was determined based on which the most effective compound was loaded into the cryogels. Next, the physical and mechanical properties of cryogels with various blending ratios of PVA-P/PVA-F and fixed amounts of CNFs were assessed, and drug release profiles and biological activities of drug-loaded cryogels were analyzed. Assessment of α-aminophosphonate derivatives showed the highest efficacy of a cinnamaldehyde-based derivative (Cinnam) against both Gram-negative and Gram-positive bacteria compared to Other derivatives. The physical and mechanical properties of cryogels showed that PVA-P/PVA-F with a 50/50 blending ratio had the highest swelling ratio (1600%), surface area (523 m2 g-1), and compression recoverability (72%) compared to that with Other blending ratios. Finally, antimicrobial and biofilm development studies showed that the cryogel loaded with a Cinnam amount of 2 mg (relative to polymer weight) showed the most sustained drug release profile over 75 h and had the highest efficacy against Gram-negative and Gram-positive bacteria. In conclusion, self-crosslinked tri-component cryogels loaded with the synthesized α-aminophosphonate derivative, having both antimicrobial and anti-biofilm formation properties, can have a significant impact on the management of uprising wound Infection.

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