Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed)  (Synonyms: PVA (Mw 30000-70000, 87-90% hydrolyzed); Poly(Ethenol) (Mw 30000-70000, 87-90% hydrolyzed))

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is a polyvinyl alcohol with a molecular weight of 30000-70000 and hydrolytic properties. The degree of hydrolysis refers to the degree to which the acetate groups in the original polyvinyl acetate are converted into hydroxyl groups during the hydrolysis process. Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) is the hydrolysis and removal of acetate groups after the polymerization of ethylene acetate. And polyvinyl alcohol is obtained. A degree of hydrolysis of 87-90% indicates that a large part of the acetate groups have been removed, resulting in a large number of hydroxyl groups in the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can be used to self-crosslink to form cryogel, which can be used as biological excipients^[1].

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) shows hemolysis index of 0.656% (sheep blood) and 0.028% (human blood)^[6].
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (5 g/25 cm³ deionised water) acts as a cell immobilization matrix for copper biosorption by yeast cells^[7].
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (1 mg/mL, 14 days) replaces serum albumin in leukemic cell (AML) cultures^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (2000-5000 ppm, diet, daily, continuously for two generations) shows no adverse toxicological or reproductive effects in either parental animals (P0 and F1) or F1 and F2 offspring in Sprague–Dawley rats^[2].
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (^14C-labeled Polyvinyl alcohol, 3 mg/kg, daily) shows vaginal absorption in Fischer 344 rats^[3].
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) shows an optimum viscosity range, with 12-15 cps of optimum viscosity in rabbits^[4].
Polyvinyl alcohol (Mw 30000-70000, 87-90% hydrolyzed) (Polyvinyl alcohol) (1 mL/day, s.c., 21 days prior to Gentamicin (HY-A0276A) induces an early sensitivity to gentamicin nephrotoxicity in rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

30000-70000 (Approximately)

(C₂H₄O)x

9002-89-5

Solid

White to off-white

C=CO.[n]

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Elsherbiny DA, et al. Self-crosslinked polyvinyl alcohol/cellulose nanofibril cryogels loaded with synthesized aminophosphonates as antimicrobial wound dressings. J Mater Chem B. 2023 Aug 2;11(30):7144-7159.  [Content Brief]

  [2]. Rodwell DE, et al. Effects of polyvinyl alcohol administered in the diet to rats on fertility, early embryonic development, growth and development. Food Chem Toxicol. 2003 May;41(5):729-37.  [Content Brief]

  [3]. Sanders JM, et al. Vaginal absorption of polyvinyl alcohol in Fischer 344 rats. Hum Exp Toxicol. 1990 Mar;9(2):71-7.  [Content Brief]

  [4]. Patton TF, et al. Ocular evaluation of polyvinyl alcohol vehicle in rabbits. J Pharm Sci. 1975 Aug;64(8):1312-6.  [Content Brief]

  [5]. Carver MP, et al. Dose-response studies of gentamicin nephrotoxicity in rats with experimental renal dysfunction. II. Polyvinyl alcohol glomerulopathy. Toxicol Appl Pharmacol. 1985 Sep 15;80(2):264-73. doi: 10.1016/0041-008x(85)90083-3.  [Content Brief]

  [6]. Alexandre N, et al. Biocompatibility and hemocompatibility of polyvinyl alcohol hydrogel used for vascular grafting--In vitro and in vivo studies. J Biomed Mater Res A. 2014 Dec;102(12):4262-75.  [Content Brief]

  [7]. Ting Y P, et al. Use of polyvinyl alcohol as a cell immobilization matrix for copper biosorption by yeast cells. Journal of Chemical Technology & Biotechnology: International Research in Process, Environmental & Clean Technology, 2000, 75(7): 541-546.

  [8]. Nishimura T, et al. Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion. Exp Hematol. 2019 Dec;80:16-20.  [Content Brief]