2. Academic Validation
  3. Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer

Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer

  • Biochem Pharmacol. 2023 Sep 29:115834. doi: 10.1016/j.bcp.2023.115834.
Chenglong Liu 1,  Limin Zhou 2,  Jia Chen 1,  Zelan Yang 1,  Shan Chen 3,  Xueqing Wang 1,  Xiaomei Liu 1,  Yang Li 1,  Can Zhang 1,  Yirong Wang 1,  Yihao Chen 1,  Huan Li 1,  Chao Shen 1,  Hui Sun 4
Affiliations

Affiliations

  • 1 College of Life Sciences, Wuhan University, Wuhan 430072, China.
  • 2 Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, China.
  • 3 School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China.
  • 4 College of Life Sciences, Wuhan University, Wuhan 430072, China; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University, Wuhan 430071, China. Electronic address: sunhui@whu.edu.cn.
PMID: 37778447 DOI: 10.1016/j.bcp.2023.115834
Abstract

The emergence of chemoresistance in cervical Cancer is extremely challenging in chemotherapy. Oxidative stress has emerged as the regulatory factor in drug resistance, but the detailed mechanism is still unknow. Stress granules, are membrane-less ribonucleoprotein-based condensates, could enhance chemoresistance by sequestering proapoptotic proteins inhibition of cell death upon exposure to drug-induced oxidative stress. Galectin-7, a member of Galectin family, exerts varied roles in tumor repression or progression in different cancers. However, its role in cervical Cancer has not been sufficiently studied. Here, we found that galectin-7 promotes cisplatin (CDDP) induced Apoptosis and associates with stress granule-nucleating protein G3BP1 degradation. With the treatment of cisplatin, galectin-7 could enhance Apoptosis by upregulating cleaved-PARP1 and the generation of Reactive Oxygen Species (ROS), promoting mitochondrial fission, and reducing mitochondrial membrane potential (MMP). Furthermore, galectin-7 also reduces resistance by facilitating cisplatin-indued stress granules clearance through galectin-7/RACK1/G3BP1 axis. All these data suggested that galectin-7 promotes cisplatin sensitivity, and it would be potential target for potentiating efficacy in cervical Cancer chemotherapy.

Keywords

Autophagy; Cisplatin; Galectin-7; Mitochondrion; Stress granule.

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