2. Academic Validation
  3. Systolic heart failure induced by butylparaben in zebrafish is caused through oxidative stress and immunosuppression

Systolic heart failure induced by butylparaben in zebrafish is caused through oxidative stress and immunosuppression

  • Ecotoxicol Environ Saf. 2023 Nov 17:268:115692. doi: 10.1016/j.ecoenv.2023.115692.
Hui Zhu 1,  Dalong Liao 2,  Muhammad Aamer Mehmood 3,  Yong Huang 4,  Wei Yuan 5,  Jia Zheng 6,  Yi Ma 7,  Yuyang Peng 5,  Guiyou Tian 5,  Xiaoping Xiao 5,  Chaohua Lan 2,  Linman Li 2,  Kewei Xu 2,  Huiqiang Lu 8,  Ning Wang 9
Affiliations

Affiliations

  • 1 School of Bioengineering, Sichuan University of Science & Engineering, Zigong 643000, China; Wuliangye Group Co., Ltd., Yibin 644007, China; Engineering Technology Research Center of Special Grain for Wine Making, Yibin 644000, China.
  • 2 School of Bioengineering, Sichuan University of Science & Engineering, Zigong 643000, China.
  • 3 School of Bioengineering, Sichuan University of Science & Engineering, Zigong 643000, China; Bioenergy Research Center, Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad 38000, Pakistan.
  • 4 Center for Drug Screening and Research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330029, Jiangxi, China.
  • 5 Center for Drug Screening and Research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China.
  • 6 Wuliangye Group Co., Ltd., Yibin 644007, China.
  • 7 School of Bioengineering, Sichuan University of Science & Engineering, Zigong 643000, China; Engineering Technology Research Center of Special Grain for Wine Making, Yibin 644000, China.
  • 8 Center for Drug Screening and Research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, China; Affiliated Hospital of Jinggangshan University, Center for Clinical Medicine Research of Jinggangshan University, China. Electronic address: luhq2@126.com.
  • 9 School of Bioengineering, Sichuan University of Science & Engineering, Zigong 643000, China; Chengdu Chongqing Shuangcheng economic circle (Luzhou) advanced technology research institute, Luzhou 646000, China; Engineering Technology Research Center of Special Grain for Wine Making, Yibin 644000, China. Electronic address: wangningzhuhui@hotmail.com.
PMID: 37981439 DOI: 10.1016/j.ecoenv.2023.115692
Abstract

Due to Butylparaben (BuP) widespread application in cosmetics, food, pharmaceuticals, and its presence as an environmental residue, human and animal exposure to BuP is common, potentially posing hazards to both human and animal health. Congenital heart disease is already a serious problem. However, the effects of BuP on the developing heart and its underlying mechanisms remain unclear. Here, zebrafish embryos were exposed to environmentally and human-relevant concentrations of BuP (0.6 mg/L, 1.2 mg/L, and 1.8 mg/L, calculated but not measured) at 6 h post-fertilization (hpf) and were treated until 72 hpf. Exposure to BuP led to cardiac morphological defects and cardiac dysfunction in zebrafish embryos, manifesting symptoms similar to systolic heart failure. The etiology of BuP-induced systolic heart failure in zebrafish embryos is multifactorial, including cardiomyocyte Apoptosis, endocardial and atrioventricular valve damage, insufficient myocardial energy, impaired CA2+ homeostasis, depletion of cardiac-resident macrophages, cardiac immune non-responsiveness, and cardiac oxidative stress. However, excessive accumulation of Reactive Oxygen Species (ROS) in the cardiac region and cardiac immunosuppression (depletion of cardiac-resident macrophages and cardiac immune non-responsiveness) may be the predominant factors. In conclusion, this study indicates that BuP is a potential hazardous substance that can cause adverse effects on the developing heart and provides evidence and insights into the pathological mechanisms by which BuP leads to cardiac dysfunction. It may help to prevent the BuP-based congenital heart disease heart failure in human through ameliorating strategies and BuP discharge policies, while raising awareness to prevent the misuse of Preservatives.

Keywords

Butylparaben; Immunosuppression; Oxidative stress; Systolic heart failure; Zebrafish.

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