2. Academic Validation
  3. Cell type-specific induction of ferroptosis to boost antitumor immunity

Cell type-specific induction of ferroptosis to boost antitumor immunity

  • Oncoimmunology. 2023 Nov 20;12(1):2282252. doi: 10.1080/2162402X.2023.2282252.
Jiao Liu 1,  Jingbo Li 2,  Rui Kang 3,  Daolin Tang 3
Affiliations

Affiliations

  • 1 DAMP Lab, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • 2 Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
  • 3 Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
PMID: 38126037 DOI: 10.1080/2162402X.2023.2282252
Abstract

Traditional Ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce Ferroptosis by targeting TRIM25-mediated GPX4 degradation in Cancer cells while sparing immune cells. This breakthrough establishes a safe and effective strategy to enhance ferroptosis-driven antitumor immunity.

Keywords

Drug discovery; GPX4; TRIM25; ferroptosis; immunotherapy.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-162065
    98.37%, Ferroptosis Inducer