2. Apoptosis
  3. Ferroptosis
  4. N6F11

N6F11 is a selective ferroptosis inducer, and can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. N6F11 initiates HMGB1-dependent antitumor immunity mediated by CD8+ T cells.

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N6F11 Chemical Structure

N6F11 Chemical Structure

CAS No. : 851398-76-0

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Based on 1 publication(s) in Google Scholar

N6F11 Related Antibodies

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Description

N6F11 is a selective ferroptosis inducer, and can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. N6F11 initiates HMGB1-dependent antitumor immunity mediated by CD8+ T cells[1][2][3][4].

In Vitro

N6F11 (5 μM, 12 h) suppresses GPX4 expression through enhanced protein degradation instead of through reduced gene transcription, induces autophagy-independent ferroptosis in PANC1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N6F11 Related Antibodies
Molecular Weight

311.19

Formula

C13H8Cl2N2OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=CC=C(C2=CC3=C(C(NC(CCl)=N3)=O)S2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (100.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2135 mL 16.0674 mL 32.1347 mL
5 mM 0.6427 mL 3.2135 mL 6.4269 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2135 mL 16.0674 mL 32.1347 mL 80.3368 mL
5 mM 0.6427 mL 3.2135 mL 6.4269 mL 16.0674 mL
10 mM 0.3213 mL 1.6067 mL 3.2135 mL 8.0337 mL
15 mM 0.2142 mL 1.0712 mL 2.1423 mL 5.3558 mL
20 mM 0.1607 mL 0.8034 mL 1.6067 mL 4.0168 mL
25 mM 0.1285 mL 0.6427 mL 1.2854 mL 3.2135 mL
30 mM 0.1071 mL 0.5356 mL 1.0712 mL 2.6779 mL
40 mM 0.0803 mL 0.4017 mL 0.8034 mL 2.0084 mL
50 mM 0.0643 mL 0.3213 mL 0.6427 mL 1.6067 mL
60 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.3389 mL
80 mM 0.0402 mL 0.2008 mL 0.4017 mL 1.0042 mL
100 mM 0.0321 mL 0.1607 mL 0.3213 mL 0.8034 mL
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N6F11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N6F11851398-76-0FerroptosisferroptosisGPX4TRIM25antitumor immunityInhibitorinhibitorinhibit

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