2. Academic Validation
  3. Adverse effects of ferroptotic therapy: mechanisms and management

Adverse effects of ferroptotic therapy: mechanisms and management

  • Trends Cancer. 2024 May;10(5):417-429. doi: 10.1016/j.trecan.2024.01.002.
Jiao Liu 1,  Rui Kang 2,  Daolin Tang 3
Affiliations

Affiliations

  • 1 DAMP Laboratory, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: 2018683073@gzhmu.edu.cn.
  • 2 Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: rui.kang@utsouthwestern.edu.
  • 3 Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: daolin.tang@utsouthwestern.edu.
PMID: 38246792 DOI: 10.1016/j.trecan.2024.01.002
Abstract

Ferroptosis, a nonapoptotic form of cell death characterized by iron accumulation and uncontrolled lipid peroxidation, holds promise as a therapeutic approach in Cancer treatment, alongside established modalities, such as chemotherapy, immunotherapy, and radiotherapy. However, recent research has raised concerns about its side effects, including damage to immune cells, hematopoietic stem cells, liver, and kidneys, the development of cachexia, and the risk of secondary tumor formation. In this review, we provide an overview of these emerging findings, with a specific emphasis on elucidating the underlying mechanisms, and underscore the critical significance of effectively managing side effects associated with targeted ferroptosis-based therapy.

Keywords

adverse effects; cancer; ferroptosis; tumor microenvironment.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-162065
    98.37%, Ferroptosis Inducer