2. Academic Validation
  3. Histone deacetylase OsHDA706 orchestrates rice broad-spectrum antiviral immunity and is impeded by a viral effector

Histone deacetylase OsHDA706 orchestrates rice broad-spectrum antiviral immunity and is impeded by a viral effector

  • Cell Rep. 2024 Feb 21;43(3):113838. doi: 10.1016/j.celrep.2024.113838.
Zihang Yang 1,  Juan Du 2,  Xiaoxiang Tan 2,  Hehong Zhang 2,  Lulu Li 2,  Yanjun Li 2,  Zhongyan Wei 2,  Zhongtian Xu 2,  Yuwen Lu 2,  Jianping Chen 1,  Zongtao Sun 3
Affiliations

Affiliations

  • 1 State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of MARA and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo 315211, China; College of Plant Protection, Henan Agricultural University, Zhengzhou, Henan 450002, China.
  • 2 State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of MARA and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo 315211, China.
  • 3 State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Biotechnology in Plant Protection of MARA and Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo 315211, China. Electronic address: sunzongtao@nbu.edu.cn.
PMID: 38386554 DOI: 10.1016/j.celrep.2024.113838
Abstract

Lysine acetylation is a dynamic post-translational modification of proteins. Extensive studies have revealed that the acetylation modulated by histone acetyltransferases and histone deacetylases (HDACs) plays a crucial role in regulating protein function. However, there has been limited focus on how HDACs regulate jasmonic acid (JA) biosynthesis in Plants. Here, we uncover that the protein stability of OsLOX14, a critical Enzyme involved in JA biosynthesis, is regulated by a histone deacetylase, OsHDA706, and is hindered by a viral protein. Our results show that OsHDA706 deacetylates OsLOX14 and enhances the stability of OsLOX14, leading to JA accumulation and an improved broad-spectrum rice Antiviral defense. Furthermore, we found that the viral protein P2, encoded by the destructive rice stripe virus, disrupts the association of OsHDA706-OsLOX14, promoting viral Infection. Overall, our findings reveal how HDAC manipulates the interplay of deacetylation and protein stability of a JA biosynthetic Enzyme to enhance plant Antiviral responses.

Keywords

CP: Immunology; CP: Plants; JA biosynthesis; antiviral defense response; deacetylation; histone deacetylase; jasmonic acid pathway; rice viruses.

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