2. Academic Validation
  3. Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis

Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis

  • J Antibiot (Tokyo). 1985 Mar;38(3):321-7. doi: 10.7164/antibiotics.38.321.
A Endo,  K Hasumi,  T Nakamura,  M Kunishima,  M Masuda
PMID: 3839224 DOI: 10.7164/antibiotics.38.321
Abstract

Dihydromonacolin L and monacolin X those are structurally related to monacolin K, a potent inhibitor of Cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these two metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.

Figures
Products