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  3. Improving physicochemical characteristics and cytotoxicity of baicalin esters by liposome encapsulation

Improving physicochemical characteristics and cytotoxicity of baicalin esters by liposome encapsulation

  • J Microencapsul. 2024 Jun;41(4):312-325. doi: 10.1080/02652048.2024.2348462.
Wei Wang 1,  Xuan Xin 1,  Mengmeng Zhang 2,  Xiaofeng Li 3,  Guanglei Zhao 4,  Wei Dong Bai 1
Affiliations

Affiliations

  • 1 College of Light Industry and Food Technology, Guangdong Key Laboratory of Science and Technology of Lingnan Special Food, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China.
  • 2 College of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China.
  • 3 College of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong, China.
  • 4 State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, Guangdong, China.
PMID: 38717966 DOI: 10.1080/02652048.2024.2348462
Abstract

The instability of ester bonds, low water solubility, and increased cytotoxicity of flavonoid glycoside esters significantly limit their application in the food industry. Therefore, the present study attempted to resolve these issues through Liposome encapsulation. The results showed that baicalin butyl ester (BEC4) and octyl ester (BEC8) have higher encapsulation and loading efficiencies and lower leakage rate from liposomes than baicalin. FTIR results revealed the location of BEC4 and BEC8 in the hydrophobic layer of liposomes, which was different from baicalin. Additionally, Liposome encapsulation improved the water solubility and stability of BEC4 and BEC8 in the digestive system and PBS but significantly reduced their cytotoxicity. Furthermore, the release rate of BEC4 and BEC8 from liposomes was lower than that of baicalin during gastrointestinal digestion. These results indicate that Liposome encapsulation alleviated the negative effects of fatty chain introduction into flavonoid glycosides.

Keywords

Liposome encapsulation; cytotoxicity; fatty chain; flavonoid glycoside esters; stability.

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