2. Academic Validation
  3. GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal

GPR55 activation improves anxiety- and depression-like behaviors of mice during methamphetamine withdrawal

  • Heliyon. 2024 Apr 27;10(9):e30462. doi: 10.1016/j.heliyon.2024.e30462.
Jinlong Zhang 1 2,  Jie Yan 1 2,  Shuyue Li 1,  Qianqian Chen 2,  Jiang Lin 2,  Yilin Peng 2,  Yuhang Liu 2,  Binbin Wang 2,  Xinrong Wei 1,  Chen Sun 3,  Shuliang Niu 1 4
Affiliations

Affiliations

  • 1 Department of Forensic Science, School of Basic Medical Science, Xinjiang Medical University, Urumqi, 830011, China.
  • 2 Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, 410000, China.
  • 3 School of Public Health, Xinjiang Medical University, Urumqi, 830011, China.
  • 4 Department of Human Anatomy, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, 830011, China.
PMID: 38720745 DOI: 10.1016/j.heliyon.2024.e30462
Abstract

Methamphetamine is a potent and highly addictive neurotoxic psychostimulant that triggers a spectrum of adverse emotional responses during withdrawal. G-protein coupled receptor 55 (GPR55), a novel endocannabinoid receptor, is closely associated with mood regulation. Herein, we developed a murine model of methamphetamine-induced anxiety- and depressive-like behavior during abstinence which showed a decreased GPR55 expression in the hippocampus. Activation of GPR55 mitigated these behavioral symptoms, concomitantly ameliorating impairments in hippocampal neurogenesis and reducing neuroinflammation. These findings underscore the pivotal role of GPR55 in mediating the neuropsychological consequences of methamphetamine withdrawal, potentially via mechanisms involving the modulation of hippocampal neurogenesis and inflammation.

Keywords

Anxiety; Depression; GPR55; Methamphetamine.

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