2. Academic Validation
  3. Paxbp1 is indispensable for the maintenance of peripheral CD4 T cell homeostasis

Paxbp1 is indispensable for the maintenance of peripheral CD4 T cell homeostasis

  • Immunology. 2024 Aug;172(4):641-652. doi: 10.1111/imm.13802.
Wenting Li 1 2,  Yang Yang 3,  Fan Zhuo 1 2,  Shenglin Liu 4,  Kaoyuan Zhang 1 2,  Wei Zhang 3 5,  Cong Huang 1 2,  Bo Yu 1 2
Affiliations

Affiliations

  • 1 Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
  • 2 Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China.
  • 3 Biomedical Research Institute, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.
  • 4 Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, College of Biological and Food Engineering, Huaihua University, Huaihua, Hunan Province, China.
  • 5 Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, China.
PMID: 38750609 DOI: 10.1111/imm.13802
Abstract

The size and condition of the peripheral CD4 T cell population determine the capacity of the immune response. Under homeostatic conditions, the size of the peripheral CD4 T cell population is maintained through turnover and survival. However, the underlying mechanisms remain inadequately understood. Here, we observed a significant decrease in the percentage of CD4 T cells in the periphery following the targeted deletion of the Paxbp1 gene in mouse T cells. In the absence of Paxbp1, naïve CD4 T cells displayed reduced surface interleukin-7 receptor levels and a decreased capacity to respond to survival signals mediated by interleukin-7. In addition, naïve CD4 T cells deficient in Paxbp1 demonstrated impaired T cell antigen receptor signalling, compromised cell cycle entry, decreased proliferation, and increased Apoptosis following stimulation, all of which contributed to the reduction in the number of peripheral CD4 T cells. Therefore, our study highlights the indispensable role of Paxbp1 in maintaining peripheral CD4 T cell homeostasis.

Keywords

IL‐7; Paxbp1; TCR; homeostasis; naïve CD4 T cells.

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