2. Academic Validation
  3. The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis

The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis

  • Cell Death Dis. 2024 May 20;15(5):347. doi: 10.1038/s41419-024-06740-4.
Zhi-Ying Shao # 1 2,  Wen-Dong Yang # 1,  Hui Qiu # 1 3,  Zhi-Hong He # 4 5,  Meng-Ru Lu 1,  Qi Shen 1,  Jin Ding 6,  Jun-Nian Zheng 7 8,  Jin Bai 9 10 11
Affiliations

Affiliations

  • 1 Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • 2 Department of Clinical Trial, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
  • 3 Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
  • 4 Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • 5 Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
  • 6 Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China. jhDingJin@zju.edu.cn.
  • 7 Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. jnzheng@xzhmu.edu.cn.
  • 8 Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China. jnzheng@xzhmu.edu.cn.
  • 9 Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China. bj@xzhmu.edu.cn.
  • 10 Center of Clinical Oncology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. bj@xzhmu.edu.cn.
  • 11 Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China. bj@xzhmu.edu.cn.
  • # Contributed equally.
PMID: 38769122 DOI: 10.1038/s41419-024-06740-4
Abstract

Colorectal Cancer (CRC) remains a significant global health issue with high incidence and mortality. Yin Yang 1 (YY1) is a powerful transcription factor that acts dual roles in gene activation and repression. High expression level of YY1 has been reported in CRC, indicating the existence of stable factors of YY1 in CRC cells. We aimed to identify the key molecules and underlying mechanisms responsible for stabilizing YY1 expression in CRC. Mass spectrometry analysis was utilized to identify USP7 as a potential molecule that interacted with YY1. Mechanically, USP7 stabilizes YY1 expression at the protein level by interfering its K63 linkage ubiquitination. YY1 exerts its oncogenic function through transcriptionally activating TRIAP1 but suppressing LC3B. In addition, at the pathological level, there is a positive correlation between the expression of YY1 and the budding of CRC. This study has revealed the intricate interplay between YY1 and USP7 in CRC, suggesting that they could serve as novel therapeutic targets or predictive biomarkers for CRC patients.

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