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  3. Rare Earth Nanoprobes for Targeted Delineation of Triple Negative Breast Cancer and Enhancement of Radioimmunotherapy

Rare Earth Nanoprobes for Targeted Delineation of Triple Negative Breast Cancer and Enhancement of Radioimmunotherapy

  • Adv Sci (Weinh). 2024 May 22:e2309992. doi: 10.1002/advs.202309992.
Zi-He Ming 1 2 3 4,  Yong-Qu Zhang 5 2 3,  Liang Song 6 7,  Min Chen 2 3,  Lin-Ling Lin 1 2 3 4,  Yue-Yang He 1 2 3 4,  Wan-Ling Liu 1 2 3 4,  Yuan-Yuan Zhu 1 2 3 4,  Yun Zhang 6 7,  Guo-Jun Zhang 1 8 2 3 4
Affiliations

Affiliations

  • 1 Cancer Center and Department of Breast and Thyroid Surgery, Xiang'an Hospital of Xiamen University School of Medicine, Xiamen University, Xiamen, Fujian, 361104, China.
  • 2 Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, 361102, China.
  • 3 Xiamen Key Laboratory of Endocrine-Related Cancer Precision Medicine, Xiang'an Hospital of Xiamen University, Xiamen, Fujian, 361102, China.
  • 4 Xiamen Research Center of Clinical Medicine in Breast and Thyroid Cancers, Xiamen, Fujian, 361102, China.
  • 5 Department of Breast Center, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
  • 6 State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350000, China.
  • 7 Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, Fujian, 361021, China.
  • 8 The Breast Center, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Beijing University Cancer Hospital, Kunming, Yunnan, 650118, China.
PMID: 38774946 DOI: 10.1002/advs.202309992
Abstract

Radiotherapy demonstrates a synergistic effect with immunotherapy by inducing a transformation of "immune cold" tumors into "immune hot" tumors in triple negative breast Cancer (TNBC). Nevertheless, the effectiveness of immunotherapy is constrained by low expression of tumor-exposed antigens, inadequate inflammation, and insufficient tumor infiltrating lymphocyte (TILs). To address this predicament, novel lutecium-based rare earth nanoparticles (RENPs) are synthesized with the aim of amplifying radiation effect and tumor immune response. The nanoprobe is characterized by neodymium-based down-conversion fluorescence, demonstrating robust photostability, biocompatibility, and targetability. The conjugation of RENPs with a CXCR4 targeted drug enables precise delineation of breast tumors using a near-infrared imaging system and improves radiation efficacy via lutetium-based radio-sensitizer in vivo. Furthermore, the study shows a notable enhancement of immune response through the induction of immunogenic cell death and recruitment of TILs, resulting in the inhibition of tumor progression both in vitro and in vivo models following the administration of nanoparticles. Hence, the novel multifunctional nanoprobes incorporating various lanthanide elements offer the potential for imaging-guided tumor delineation, radio-sensitization, and immune activation post-radiation, thus presenting an efficient radio-immunotherapeutic approach for TNBC.

Keywords

radioimmunotherapy; radiosensitization; rare‐earth nanoparticles; second near‐infrared‐fluorescence imaging; triple negative breast cancer.

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