2. Immunology/Inflammation Apoptosis Autophagy
  3. PD-1/PD-L1 Apoptosis Autophagy
  4. Atezolizumab

Atezolizumab  (Synonyms: MPDL3280A)

Cat. No.: HY-P9904 Purity: ≥98.0%
COA

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Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

For research use only. We do not sell to patients.

CAS No. : 1380723-44-3

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Based on 27 publication(s) in Google Scholar

Atezolizumab Related Antibodies

Top Publications Citing Use of Products

    Atezolizumab purchased from MedChemExpress. Usage Cited in: EJNMMI Res. 2020 Jun 15;10(1):64.  [Abstract]

    Western blot analysis of total cell lysates using anti-PD-L1 (Atezolizumab, 6.91 nM) and anti-β-actin antibody between LoVo, LS174T, SW620, and RKO in vitro.

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    Description

    Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

    Isotype

    Human IgG1 kappa
    Recommend Isotype Controls
    Species

    Humanized
    In Vitro

    Atezolizumab (0, 2.5, 5, 10, 20, and 40?μg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
    Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway. Atezolizumab (10?μg/ml; 24?hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Atezolizumab Related Antibodies
    Clinical Trial
    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Atezolizumab]
    Shipping

    Shipping with dry ice.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Flow cytometry analysis of PD-L1 overexpression HEK293 cells labelling PD-L1 with Atezolizumab at 67nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
    Purity & Documentation

    Purity: 98.98%

    COA (291 KB)

    Inhibitory Antibodies User Guide (602 KB)
    References
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    Atezolizumab Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Atezolizumab1380723-44-3MPDL3280APD-1/PD-L1ApoptosisAutophagyPD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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