2. Academic Validation
  3. Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway

Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway

  • Imeta. 2024 Jan 15;3(1):e165. doi: 10.1002/imt2.165.
Ling Wang 1 2 3 4,  Yi-Xuan Tu 1 2 3,  Lu Chen 1,  Ke-Chun Yu 1,  Hong-Kai Wang 1,  Shu-Qiao Yang 1,  Yuan Zhang 1,  Shuai-Jie Zhang 1,  Shuo Song 1,  Hong-Li Xu 5,  Zhu-Cheng Yin 5,  Ming-Qian Feng 1,  Jun-Qiu Yue 6,  Xiang-Hong Huang 7,  Tang Tang 8,  Shao-Zhong Wei 9,  Xin-Jun Liang 5,  Zhen-Xia Chen 1 2 3
Affiliations

Affiliations

  • 1 Hubei Hongshan Laboratory, Hubei Key Laboratory of Agricultural Bioinformatics, Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, College of Life Science and Technology, College of Biomedicine and Health, Interdisciplinary Sciences Institute Huazhong Agricultural University Wuhan China.
  • 2 Shenzhen Institute of Nutrition and Health Huazhong Agricultural University Shenzhen China.
  • 3 Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
  • 4 Department of Pharmaceutical Chemistry University of California-San Francisco San Francisco California USA.
  • 5 Department of Medical Oncology, Hubei Cancer Hospital, Tongji Medical College Huazhong Agricultural University Wuhan China.
  • 6 Department of Pathology, Hubei Cancer Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
  • 7 Wuhan Myhalic Biotechnological Co., Ltd Wuhan China.
  • 8 Wuhan Metware Biotechnology Co., Ltd Wuhan China.
  • 9 Department of Gastrointestinal Oncology Surgery, Hubei Cancer Hospital, Tongji Medical College Huazhong Agricultural University Wuhan China.
PMID: 38868519 DOI: 10.1002/imt2.165
Abstract

Consumption of dietary fiber and anthocyanin has been linked to a lower incidence of colorectal Cancer (CRC). This study scrutinizes the potential antitumorigenic attributes of a black rice diet (BRD), abundantly rich in dietary fiber and anthocyanin. Our results demonstrate notable antitumorigenic effects in mice on BRD, indicated by a reduction in both the size and number of intestinal tumors and a consequent extension in life span, compared to control diet-fed counterparts. Furthermore, fecal transplants from BRD-fed mice to germ-free mice led to a decrease in colonic cell proliferation, coupled with maintained integrity of the intestinal barrier. The BRD was associated with significant shifts in gut microbiota composition, specifically an augmentation in probiotic strains Bacteroides uniformis and Lactobacillus. Noteworthy changes in gut metabolites were also documented, including the upregulation of indole-3-lactic acid and indole. These metabolites have been identified to stimulate the intestinal Aryl Hydrocarbon Receptor pathway, inhibiting CRC cell proliferation and colorectal tumorigenesis. In summary, these findings propose that a BRD may modulate the progression of intestinal tumors by fostering protective gut microbiota and metabolite profiles. The study accentuates the potential health advantages of whole-grain foods, emphasizing the potential utility of black rice in promoting health.

Keywords

black rice diet; colorectal cancer; gut metabolites; gut microbiome.

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