2. Academic Validation
  3. CD177 on neutrophils engages stress-related behavioral changes in male mice

CD177 on neutrophils engages stress-related behavioral changes in male mice

  • Brain Behav Immun. 2024 Jun 12:120:403-412. doi: 10.1016/j.bbi.2024.06.011.
Ling Meng 1,  Mi Zhou 1,  Yunpeng Wang 2,  Yiming Pan 3,  Zheng Chen 4,  Bin Wu 5,  Yan Zhao 6
Affiliations

Affiliations

  • 1 Department of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 2 Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
  • 3 Laboratory of Developmental Biology, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.
  • 4 Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 5 Growth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address: binwoo.ni@gmail.com.
  • 6 Department of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: zmytracy@hospital.cqmu.edu.cn.
PMID: 38871062 DOI: 10.1016/j.bbi.2024.06.011
Abstract

Persistent psychological stress can affect immune homeostasis and is a key factor in the development of depression. Many efforts are focused on the identifcation of pathways that link the immune system and mood disorders. Here, we found that psychological stress caused an increase in the frequency of brain-associated neutrophils and the level of neutrophil-specific antigen CD177 on peripheral neutrophils in male mice. Upregulated levels of blood CD177 are associated with depression in humans. Neutrophil depletion or CD177 deficiency protected mice from stress-induced behavioral deficits. Importantly, adoptive transfer of CD177+ neutrophils from stressed mice increased the frequency of brain-associated leukocytes, including neutrophils, and caused behavioral defects in naive mice. These effects may be related to the endothelial adhesion advantage of CD177+ neutrophils and the interference of serine protease on endothelial junction. Our findings suggest a critical link between circulating CD177+ neutrophils and psychological stress-driven behavioral disorder.

Keywords

Behavior; CD177; Innate immunity; Neutrophil; Psychological stress.

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