2. Academic Validation
  3. Polyhedral magnetic nanoparticles induce apoptosis in gastric cancer stem cells and suppressing tumor growth through magnetic force generation

Polyhedral magnetic nanoparticles induce apoptosis in gastric cancer stem cells and suppressing tumor growth through magnetic force generation

  • J Control Release. 2024 Jul 24:373:370-384. doi: 10.1016/j.jconrel.2024.07.041.
Jianhua Wang 1,  Qiang Hou 2,  Jie Qu 2,  Xueping Huo 3,  Huiting Li 3,  Yangmeng Feng 3,  Qiyu Wang 2,  Le Chang 4,  Cuixiang Xu 5
Affiliations

Affiliations

  • 1 Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 710068 Xi'an, China; Second Department of General Surgery, Shaanxi Provincial People's Hospital, 710068 Xi'an, China.
  • 2 Department of Graduate School, Yan'an University, 716000 Yan'an, China.
  • 3 Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 710068 Xi'an, China; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, 710068 Xi'an, China.
  • 4 Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 710068 Xi'an, China; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, 710068 Xi'an, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, 710049 Xi'an, China. Electronic address: changlechangle0113@163.com.
  • 5 Shaanxi Provincial Key Laboratory of Infection and Immune Diseases, Shaanxi Provincial People's Hospital, 710068 Xi'an, China; Shaanxi Engineering Research Center of Cell Immunology, Shaanxi Provincial People's Hospital, 710068 Xi'an, China. Electronic address: xucuixiang1129@163.com.
PMID: 39032573 DOI: 10.1016/j.jconrel.2024.07.041
Abstract

Gastric Cancer is a prevalent malignant tumor worldwide, posing challenges due to its poor prognosis and limited treatment options. Cancer Stem Cells (CSCs) were demonstrated as a subset of Cancer cells responsible for tumor initiation and progression, and their inherent resistance to conventional chemotherapy and radiotherapy critically contributes to tumor recurrence and metastasis. Promoting the eradication of Cancer Stem Cells is crucial for enhancing the efficacy of Cancer treatments. This study introduces a novel therapeutic strategy utilizing polyhedral magnetic nanoparticles (PMNPs) functionalized with CD44 Antibodies and cell-penetrating Peptides (CPPs) to improve uptake by gastric Cancer Stem Cells (MCSCs). PMNPs, synthesized via thermal decomposition, exhibited a diameter of 90 nm ± 9 nm and a saturation magnetization of 79.9 emu/g. Functionalization enhanced their uptake capabilities. Under a rotating magnetic field (RMF) of 15 Hz, PMNPs disrupted cellular structure, leading to Apoptosis and Ferroptosis in MCSCs. The in vitro studies showed significant reduction in MCSCs viability, while in vivo studies demonstrated tumor growth suppression with minimal side effects and high biocompatibility. This work presents a novel strategy for designing magnetic nanoparticles to mechanically destroy Cancer Stem Cells, offering a more efficient and safety treatment option for gastric Cancer.

Keywords

Ferroptosis; Magnetic force; Polyhedral magnetic nanoparticles; Tumor inhibition.

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