2. Academic Validation
  3. Plasma Membrane-Derived Biomimetic Apoptotic Nanovesicles Targeting Inflammation and Cartilage Degeneration for Osteoarthritis

Plasma Membrane-Derived Biomimetic Apoptotic Nanovesicles Targeting Inflammation and Cartilage Degeneration for Osteoarthritis

  • Small Methods. 2024 Jul 22:e2400660. doi: 10.1002/smtd.202400660.
Zongyi Li 1 2 3,  Quhan Cheng 4,  Luoyao Lin 1 2 3,  Xiaoling Fu 2 3 5,  Yingjun Wang 1 2 3
Affiliations

Affiliations

  • 1 School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
  • 2 National Engineering Research Center for Tissue Restoration and Reconstruction and Innovation Center for Tissue Restoration and Reconstruction, Guangzhou, 510006, China.
  • 3 Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou, 510006, China.
  • 4 Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.
  • 5 School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, 511442, China.
PMID: 39036830 DOI: 10.1002/smtd.202400660
Abstract

Osteoarthritis (OA) is a degenerative whole-joint disease in which the synovium and joint cartilage become inflamed and damaged. The essential role of inflammation in the development of OA has been recognized recently. Accordingly, simultaneous regulation of local inflammation and tissue degeneration is proposed as a promising therapeutic strategy. Herein, multifunctional biomimetic apoptotic nanovesicles (Apo-NVs) are constructed with plasma membrane derived from apoptotic T cells. The anti-inflammatory microRNA-124 is further encapsulated into Apo-NVs in the hope of achieving an enhanced immunomodulatory effect. It is found that apoptotic nanovesicles, including Apo-NVs and Apo-NVs-miR-124, both efficiently promote the M2 repolarization of M1 macrophages and inhibit the degenerative phenotype of chondrocytes. Further in vivo studies show that Apo-NVs and Apo-NVs-miR-124 alleviate synovial inflammation and protect cartilage tissue from degeneration in OA mice. The study highlights the potential of Apo-NVs in treating OA and Other inflammation-related diseases.

Keywords

apoptotic nanovesicles; cartilage protection; macrophage repolarization; osteoarthritis; synovitis.

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