2. Academic Validation
  3. Liposomes Loaded with 5-Fluorouracil Can Improve the Efficacy in Pathological Scars

Liposomes Loaded with 5-Fluorouracil Can Improve the Efficacy in Pathological Scars

  • Int J Nanomedicine. 2024 Jul 19:19:7353-7365. doi: 10.2147/IJN.S466221.
Yixin Li # 1 2 3 4 5 6,  Qi Sun # 2 3 7,  Lingjia Hao 1 8,  Han Shan 2 3 7,  Zixi Jiang 1 2 3 4 5 6,  Ying Wang 1 2 3 4 5 6,  Zeyu Chen 2 3 7,  Wu Zhu 1 2 3 4 5 6,  Shuang Zhao 1 2 3 4 5 6
Affiliations

Affiliations

  • 1 Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
  • 2 Furong Laboratory (Precision Medicine), Changsha, 410008, People's Republic of China.
  • 3 National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
  • 4 Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
  • 5 Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
  • 6 National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
  • 7 School of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, People's Republic of China.
  • 8 Xiangya School of Medicine, Central South University, Changsha, 410083, People's Republic of China.
  • # Contributed equally.
PMID: 39050869 DOI: 10.2147/IJN.S466221
Abstract

Introduction: Pathological scars, such as hypertrophic scars and keloids, are characterized by the proliferation of fibroblasts and the deposition of collagen that often cause pruritus, pain, and disfigurement. Due to their high incidence and deformity, pathological scars have resulted in severe physical and psychological trauma for patients. Intralesional injection of 5-fluorouracil (5-Fu) is a recommended option for treating pathological scars. However, the efficacy of 5-Fu injection was limited and unstable due to limited drug penetration and short retention time.

Methods: Liposomes are promising carriers that have advantages, such as high biocompatibility, controlled release property, and enhanced clinical efficacy. Here, we constructed a transdermal 5-Fu-loaded Liposome (5-Fu-Lip) to provide a more effective and safer modality to scar treatment.

Results: Compared to 5-Fu, 5-Fu-Lip showed superior ability in inhibiting primary keloid fibroblasts proliferation, migration, and collagen deposition, and also significantly inhibited human umbilical vein endothelial cells (HUVECs) proliferation and microvessel construction. In vivo experiments demonstrated that 5-Fu-Lip can significantly reduce the severity of hypertrophic scars in a rabbit ear wounding model.

Discussion: 5-Fu-Lip provides a promising strategy to improve drug efficacy, which has great potential in the treatment of pathological scars.

Keywords

5-fluorouracil; fibroblast; liposome; pathological scar.

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