2. Academic Validation
  3. Biomimetic nanocomplex based corneal neovascularization theranostics

Biomimetic nanocomplex based corneal neovascularization theranostics

  • J Control Release. 2024 Aug 9:374:50-60. doi: 10.1016/j.jconrel.2024.08.002.
Jinfa Ye 1,  Yuhang Cheng 1,  Xiaofei Wen 2,  Yun Han 1,  Xingyuan Wei 1,  Yiming Wu 1,  Chuan Chen 3,  Min Su 4,  Shundong Cai 1,  Jintao Pan 1,  Gang Liu 5,  Chengchao Chu 6
Affiliations

Affiliations

  • 1 Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, China.
  • 2 Department of Interventional Radiology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361000, China.
  • 3 Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China. Electronic address: cc@xmmc.edu.cn.
  • 4 Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China.
  • 5 State Key Laboratory of Physical Chemistry of Solid Surfaces & The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361002, China; Shen Zhen Research Institute of Xiamen University, Shenzhen 518057, China. Electronic address: gangliu.cmitm@xmu.edu.cn.
  • 6 Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, China; Shen Zhen Research Institute of Xiamen University, Shenzhen 518057, China. Electronic address: chuchengchao@xmu.edu.cn.
PMID: 39111599 DOI: 10.1016/j.jconrel.2024.08.002
Abstract

Corneal neovascularization (CNV) is a major cause of blindness worldwide. However, the recent drug treatment is limited by repeated administration and low drug bioavailability. In this work, SU6668 (an inhibitor of Receptor Tyrosine Kinases) and indocyanine green (ICG) are loaded onto poly(lactic-co-glycolic acid) (PLGA) nanoparticles, and then coated with anti-VEGFR2 single chain antibody (AbVr2 scFv) genetically engineered cell membrane vesicles. The nanomedicine is delivered via eye drops, and the hyperthermia induced by laser irradiation could block the blood vessels. Meanwhile, the photothermal effect can also cause the degradation of nanomaterials and release chemotherapeutic drugs in the blocked area, thereby continuously inhibit the neovascularization. Furthermore, SU6668 could inhibit the expression of heat shock protein 70 (HSP70), promoting the cell death induced by photothermal effect. In conclusion, the combination of photothermal and chemotherapy drugs provides a novel, effective and safe approach for the treatment of CNV.

Keywords

Combined treatment; Corneal neovascularization; Nanomedicine; Photothermal therapy; Theranostics.

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