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  3. Synergistic effect of cerium chloride and calcium chloride alters calcium signaling in keratinocytes to promote epidermal differentiation

Synergistic effect of cerium chloride and calcium chloride alters calcium signaling in keratinocytes to promote epidermal differentiation

  • Biosci Biotechnol Biochem. 2024 Nov 22;88(12):1432-1441. doi: 10.1093/bbb/zbae131.
Kei Tsukui 1,  Masamitsu Suzuki 2,  Miyu Amma 2,  Yoshihiro Tokudome 3 4
Affiliations

Affiliations

  • 1 The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima, Japan.
  • 2 Zeria Pharmaceutical Co., Ltd., Tokyo, Japan.
  • 3 Graduate School of Science and Engineering/Advanced Health Sciences, Saga University, Saga, Japan.
  • 4 Laboratory of Cosmetic Sciences, Institute of Ocean Energy, Saga University, Saga, Japan.
PMID: 39333009 DOI: 10.1093/bbb/zbae131
Abstract

Epidermal keratinocytes undergo morphological and functional changes during differentiation, eventually being enucleated to become corneocytes. Calcium has been shown to be involved in various cellular functions of epidermal cells, including proliferation, differentiation, and Apoptosis. Cerium is a lanthanide-series element and rare earth metal. For skin, cerium oxide has been investigated for use in absorbing UV and promoting wound healing. However, the functions and physiological effects of inorganic cerium on the skin have rarely been investigated. Here, we focused on cerium's function in epidermal keratinocytes and its interaction with calcium by investigating their effects on cell differentiation and intracellular calcium concentration. This study showed that applying cerium chloride to epidermal keratinocytes altered calcium signaling. It also suggested that cerium and calcium induced an increase in intracellular calcium concentration and promoted keratinocyte differentiation.

Keywords

calcium signaling; cell differentiation; cerium; epidermis.

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