2. Academic Validation
  3. Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway

Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway

  • Int Immunopharmacol. 2024 Dec 5;142(Pt B):113245. doi: 10.1016/j.intimp.2024.113245.
Qiufei Wang 1,  Huaqiang Tao 2,  Heng Wang 2,  Kai Chen 3,  Pengfei Zhu 2,  Wenxiang Chen 2,  Feng Shi 4,  Ye Gu 5,  Yaozeng Xu 6,  Dechun Geng 7
Affiliations

Affiliations

  • 1 Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Orthopedics, Changshu Hospital Affiliated to Soochow University, First People's Hospital of Changshu City, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Orthopedics, Central Laboratory, Changshu Hospital Affiliated to Soochow University, First People's Hospital of Changshu City, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
  • 2 Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
  • 3 Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Orthopedics, Hai'an People's Hospital, Zhongba Road 17, Hai'an, Jiangsu, China.
  • 4 Department of Dermatology and Venereology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China. Electronic address: bruceshi1227@163.com.
  • 5 Department of Orthopedics, Changshu Hospital Affiliated to Soochow University, First People's Hospital of Changshu City, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Orthopedics, Central Laboratory, Changshu Hospital Affiliated to Soochow University, First People's Hospital of Changshu City, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: edwinguye@126.com.
  • 6 Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: xuyaozeng@163.com.
  • 7 Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: szgengdc@suda.edu.cn.
PMID: 39340985 DOI: 10.1016/j.intimp.2024.113245
Abstract

Periprosthetic osteolysis (PPO), caused by wear particles, is a significant complication of total joint replacement, leading to prosthesis failure. Previous research has highlighted the crucial role of osteoclast-induced bone destruction in PPO progression. Albiflorin (AF), a monoterpene glycoside from Paeonia lactiflora, is a key active ingredient known for its antioxidant and anti-inflammatory properties. Although AF has shown promise in treating various conditions, its impact on osteoclasts and PPO remains unexplored. Our study revealed that AF could effectively inhibit osteoclast differentiation to reduce overactivated bone resorption and effectively inhibit the accumulation of Reactive Oxygen Species (ROS) induced by wear particles. In vitro experiments also confirmed that AF could effectively inhibit the PI3K/Akt signaling pathway and inhibit inflammation to regulate osteoclast generation. Studies in animal models have also verified the antioxidant and anti-inflammatory properties of AF. In summary, the above studies indicate that AF inhibits osteoclastogenesis via inhibiting ROS accumulation and the PI3K/Akt signaling pathway, which may be a potential therapeutic method for PPO.

Keywords

Albiflorin; Inflammation; Osteoclastogenesis; Osteolysis; Reactive oxygen species.

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