2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Albiflorin

Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects.

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Albiflorin Chemical Structure

Albiflorin Chemical Structure

CAS No. : 39011-90-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 209 In-stock
Solution
10 mM * 1 mL in DMSO USD 209 In-stock
Solid
1 mg USD 94 In-stock
5 mg USD 198 In-stock
10 mg USD 337 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Albiflorin:

Albiflorin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects[1][2].

In Vitro

Albiflorin (50-200 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates glutamate (Glu)-induced reduction of cell viability[1].
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment significantly ameliorates Glu-induced reduction of nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation, and B-cell lymphoma 2 (Bcl-2)/Bax ratio[1].
Albiflorin (100 μM; pretreated for 3 hours; PC12 cells) treatment enhances phosphorylation of AKT and its downstream element GSK-3β[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Albiflorin Related Antibodies

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 50 μM, 100 μM, 200 μM
Incubation Time: Pretreated for 3 hours
Result: Significantly ameliorated Glu-induced reduction of cell viability.

Apoptosis Analysis[1]

Cell Line: PC12 cells
Concentration: 100 μM
Incubation Time: Pretreated for 3 hours
Result: Significantly ameliorated Glu-induced reduction of nuclear and mitochondrial apoptotic alteration.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 100 μM
Incubation Time: Pretreated for 3 hours
Result: Enhanced phosphorylation of AKT and its downstream element GSK-3β.
In Vivo

Albiflorin (50?mg/kg; intraperitoneal injection; once a day; for 15 days; Wistar rats) treatment significantly increases the paw withdrawal threshold (PWT) on the 11th and 15th day after surgery in rats. Albiflorin could inhibit the activation of p38 MAPK pathway in spinal microglia and subsequent upregulated IL-1β and TNF-α. Albiflorin displays remarkable effects on inhibiting the activation of astrocytes, suppressing the overelevated expression of phosphorylation of c-JNK (p-JNK) in astrocytes, and decreasing the content of chemokine CXCL1 in the spinal cord[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (7-week-old; 200-220 g) bearing chronic constriction injury (CCI)[2]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; once a day; for 15 days
Result: Significantly increased the paw withdrawal threshold (PWT) on the 11th and 15th day after surgery.
Molecular Weight

480.46

Formula

C23H28O11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)OC[C@@]2([C@@]([C@H](O)C[C@@]3(OC2=O)C)([H])C4)[C@]43O[C@@H]5O[C@@H]([C@@H](O)[C@H](O)[C@H]5O)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (208.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (208.13 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0813 mL 10.4067 mL 20.8134 mL
5 mM 0.4163 mL 2.0813 mL 4.1627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (208.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.67%

SDS (251 KB)

COA (260 KB) HNMR (277 KB) RP-HPLC (168 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.0813 mL 10.4067 mL 20.8134 mL 52.0335 mL
5 mM 0.4163 mL 2.0813 mL 4.1627 mL 10.4067 mL
10 mM 0.2081 mL 1.0407 mL 2.0813 mL 5.2033 mL
15 mM 0.1388 mL 0.6938 mL 1.3876 mL 3.4689 mL
20 mM 0.1041 mL 0.5203 mL 1.0407 mL 2.6017 mL
25 mM 0.0833 mL 0.4163 mL 0.8325 mL 2.0813 mL
30 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7344 mL
40 mM 0.0520 mL 0.2602 mL 0.5203 mL 1.3008 mL
50 mM 0.0416 mL 0.2081 mL 0.4163 mL 1.0407 mL
60 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8672 mL
80 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6504 mL
100 mM 0.0208 mL 0.1041 mL 0.2081 mL 0.5203 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Albiflorin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Albiflorin39011-90-0Reactive Oxygen SpeciesBcl-2glutamateneurodegenerativeROSneuroprotectivemonoterpeneglycosideanti-inflammatoryantioxidantantinociceptiveInhibitorinhibitorinhibit

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