2. Academic Validation
  3. Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors

Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors

  • Commun Biol. 2024 Oct 18;7(1):1346. doi: 10.1038/s42003-024-07040-5.
Jingyu Chen 1,  Xueru Wang 2,  Zijie Li 1,  Hui Yuan 2,  Xuejiao Wang 1,  Yang Yun 3,  Xu Wu 4,  Pingting Yang 5,  Ling Qin 6
Affiliations

Affiliations

  • 1 Department of Physiology, School of Life Sciences, China Medical University, Shenyang, China.
  • 2 Laboratory of Hearing Research, School of Life Sciences, China Medical University, Shenyang, China.
  • 3 Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China.
  • 4 Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang, China.
  • 5 Department of Rheumatology and Immunology, The First Hospital of China Medical University, Shenyang, China.
  • 6 Laboratory of Hearing Research, School of Life Sciences, China Medical University, Shenyang, China. qinlingling@yahoo.com.
PMID: 39420035 DOI: 10.1038/s42003-024-07040-5
Abstract

Tinnitus has been identified as a potential contributor to anxiety. Thalamo-cortical pathway plays a crucial role in the transmission of auditory and emotional information, but its casual link to tinnitus-associated anxiety remains unclear. In this study, we explore the neural activities in the thalamus and cortex of the sodium salicylate (NaSal)-treated mice, which exhibit both hyperacusis and anxiety-like behaviors. We find an increase in gamma band oscillations (GBO) in both auditory cortex (AC) and prefrontal cortex (PFC), as well as phase-locking between cortical GBO and thalamic neural activity. These changes are attributable to a suppression of GABAergic neuron activity in thalamic reticular nucleus (TRN), and optogenetic activation of TRN reduces NaSal-induced hyperacusis and anxiety-like behaviors. The elevation of endocannabinoid (eCB)/ Cannabinoid Receptor 1 (CB1R) transmission in TRN contributes to the NaSal-induced abnormalities. Our results highlight the regulative role of TRN in the auditory and limbic thalamic-cortical pathways.

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