2. Academic Validation
  3. A Tetrahedral Framework DNA-Based Bioswitchable miR-150 Delivery System for Sepsis

A Tetrahedral Framework DNA-Based Bioswitchable miR-150 Delivery System for Sepsis

  • ACS Appl Mater Interfaces. 2024 Oct 30;16(43):58477-58488. doi: 10.1021/acsami.4c14928.
Yutian He 1,  Zhiqiang Liu 1,  Songhang Li 1,  Shengnan Liao 1,  Bicai Tang 1,  Yunfeng Lin 1 2 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
  • 2 Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu, Sichuan 610041, China.
  • 3 National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
PMID: 39422161 DOI: 10.1021/acsami.4c14928
Abstract

Sepsis is a disease with high morbidity and mortality, for which effective treatments are lacking. In recent years, MicroRNAs (miRs) have been shown to regulate numerous biological processes and can function as therapeutic options for various diseases. However, the poor stability and cell entry properties of miRs have greatly limited their clinical application. In this study, we developed a tetrahedral framework nucleic acid (tFNA)-based bioswitchable miR delivery system (BiRDS) to deliver miR-150 for the treatment of sepsis. BiRDS showed anti-inflammatory effects both in vitro and in vivo by regulating the NF-κB and Notch1 pathways. Therefore, this system holds promise as an ideal candidate for tackling systemic inflammation and multiorgan dysfunction in septic patients in the future.

Keywords

RNA delivery; inflammation; miRNAs; sepsis; tetrahedral framework nucleic acids.

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