2. Academic Validation
  3. Stearoyl CoA desaturase inhibition can effectively induce apoptosis in bladder cancer stem cells

Stearoyl CoA desaturase inhibition can effectively induce apoptosis in bladder cancer stem cells

  • Cancer Cell Int. 2024 Oct 29;24(1):357. doi: 10.1186/s12935-024-03540-w.
Yuchen Li 1,  Chiyuan Piao 2,  Chuize Kong 3
Affiliations

Affiliations

  • 1 Department of Urology, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang City, 110000, Liaoning Province, People's Republic of China.
  • 2 Department of Urology, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang City, 110000, Liaoning Province, People's Republic of China. cypiao@cmu.edu.cn.
  • 3 Department of Urology, The First Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang City, 110000, Liaoning Province, People's Republic of China. kongchuize_cmu@sina.cn.
PMID: 39472909 DOI: 10.1186/s12935-024-03540-w
Abstract

Bladder Cancer stands as one of the most prevalent cancers worldwide. While our previous research confirmed the significant role of stearoyl-CoA desaturase (SCD) in bladder Cancer, the underlying reasons for its abnormal overexpression remain largely unknown. Moreover, the distinct response to SCD inhibitors between Cancer Stem Cells (CSCs) and adherent cultured cell lines lacks clear elucidation. Therefore, in this experiment, we aim to conduct an analysis and screening of the SCD transcription start site, further seeking critical transcription factors involved. Simultaneously, through experimental validation, we aim to explore the pivotal role of endoplasmic reticulum stress/unfolded protein response in drug sensitivity among Cancer Stem Cells. Additionally, our RNA-seq and lipid metabolism analysis revealed the significant impact of nervonic acid on altering the proliferative capacity of bladder Cancer cell lines.

Keywords

Apoptosis; Bladder cancer; Cancer stem cells (CSCs); DNA damage (DDR); ER stress; Nervonic acid; Stearoyl-CoA desaturase.

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