2. Academic Validation
  3. Therapeutic potential of the probiotic Lactiplantibacillus plantarum BX 62 and its postbiotics in alleviating rheumatoid arthritis in mice

Therapeutic potential of the probiotic Lactiplantibacillus plantarum BX 62 and its postbiotics in alleviating rheumatoid arthritis in mice

  • Curr Res Food Sci. 2024 Nov 5:9:100915. doi: 10.1016/j.crfs.2024.100915.
Qi Qin 1 2,  Gang Hu 3 4,  Xiaoni Zhou 5,  Ruizhe Zhu 4,  Jianying Chen 4,  Kangtai Zeng 6,  Jingwu Wu 7,  Jing Wei 4,  Tingtao Chen 3 4 8,  Xusheng Guo 1 2
Affiliations

Affiliations

  • 1 School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
  • 2 Probiotics and Life Health Institute, Lanzhou University, Lanzhou, 730000, China.
  • 3 School of Life Sciences, Nanchang University, Nanchang, 330031, China.
  • 4 National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, 330031, Jiangxi, China.
  • 5 Department of Obstetrics & Gynecology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
  • 6 School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China.
  • 7 Second Clinical Medical College, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
  • 8 School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330036, Jiangxi, China.
PMID: 39582573 DOI: 10.1016/j.crfs.2024.100915
Abstract

This study comprehensively investigated the probiotic potential of Lactiplantibacillus plantarum and its derived postbiotics in alleviating rheumatoid arthritis (RA) symptoms in mice. In vitro analyses established the probiotic characteristics of L. plantarum, highlighting its acid tolerance, bile salt resistance, and adhesion abilities. Subsequent in vivo experiments demonstrated that administering live L. plantarum significantly reduced arthritis scores, paw oedema, and intestinal permeability in RA mice, indicating its therapeutic potential. Furthermore, the study explored the effects of L. plantarum-derived postbiotics, including both the cellular remnants and supernatant, on RA. Notably, both the inactivated body of L. plantarum and its supernatant effectively reduced osteoarthritic damage, intestinal pathological changes, autoantibody levels, cytokine imbalances, and oxidative stress in RA mice. Additionally, qPCR analysis revealed that L. plantarum interventions restored gut microbiota composition towards a healthier profile, resembling that of normal mice. Collectively, these findings underscore the therapeutic benefits of L. plantarum and its postbiotics in ameliorating RA symptoms, emphasising their potential as novel therapeutic agents for managing RA.

Keywords

Lactiplantibacillus plantarum; Osteoarthritis; Postbiotic; Rheumatoid arthritis.

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